Kinetic and Dynamic Description of Caffeine

Alsabri, Sami G.; Mari, Walid; Younes, Sara; Alsadawi, Murad A.; Oroszi, Terry

doi:10.1089/caff.2017.0011

Cited by 39 publications

(17 citation statements)

References 38 publications

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“…Since coffee is a complex mixture containing more than 1000 substances, including CGAs and caffeine [19], it has been reported that some of its beneficial metabolic effects might be mediated, at least partially, by caffeine [65,66,67,68]. Caffeine is completely absorbed in the small intestine and needs around 45 min to become 99% bioavailable [69] and distributed to the tissues where caffeine is known to increase lipolysis and stimulate catecholamine secretion, which can increase energy expenditure [70]. It is finally eliminated from serum and tissues within 4–5 h in urine (95%) [71], after extensive hepatic metabolism by CYP1A2.…”

Section: Discussionmentioning

confidence: 99%

Green Coffee Extract Improves Cardiometabolic Parameters and Modulates Gut Microbiota in High-Fat-Diet-Fed ApoE-/- Mice

Caro-Gómez

Sierra²,

Escobar³

et al. 2019

Nutrients

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Chlorogenic acids (CGA) are the most abundant phenolic compounds in green coffee beans and in the human diet and have been suggested to mitigate several cardiometabolic risk factors. Here, we aimed to evaluate the effect of a water-based standardized green coffee extract (GCE) on cardiometabolic parameters in ApoE-/- mice and to explore the potential underlying mechanisms. Mice were fed an atherogenic diet without (vehicle) or with GCE by gavage (equivalent to 220 mg/kg of CGA) for 14 weeks. We assessed several metabolic, pathological, and inflammatory parameters and inferred gut microbiota composition, diversity, and functional potential. Although GCE did not reduce atherosclerotic lesion progression or plasma lipid levels, it induced important favorable changes. Specifically, improved metabolic parameters, including fasting glucose, insulin resistance, serum leptin, urinary catecholamines, and liver triglycerides, were observed. These changes were accompanied by reduced weight gain, decreased adiposity, lower inflammatory infiltrate in adipose tissue, and protection against liver damage. Interestingly, GCE also modulated hepatic IL-6 and total serum IgM and induced shifts in gut microbiota. Altogether, our results reveal the cooccurrence of these beneficial cardiometabolic effects in response to GCE in the same experimental model and suggest potential mediators and pathways involved.

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Section: Discussionmentioning

confidence: 99%

Green Coffee Extract Improves Cardiometabolic Parameters and Modulates Gut Microbiota in High-Fat-Diet-Fed ApoE-/- Mice

Caro-Gómez

Sierra²,

Escobar³

et al. 2019

Nutrients

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“…Caffeine intake at high doses, exceeding 500-600mg (equivalent to 4-7 cups/day) can cause anxiety, tremor and tachycardia but generally, life-threatening caffeine overdoses have been attributed to ingestion of caffeine-containing medications rather than caffeinated foods or beverages. The caffeine lethal dose has been estimated to be roughly 140-170mg/kg, which is equivalent to 8-10g/day (approximately 100 cups of coffee) [41].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Caffeine Consumption on Fertilization and IVF Outcomes: A Review and Presentation of Original Data

Yovich¹,

Zaidi²,

Joesbury³

et al. 2019

JOGRS

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Caffeine is widely consumed by both men and women but its pharmacological effects have not been well studied in the area of assisted reproduction. Various authorities indicate that caffeine consumption up to 400 mg per day is safe, but caution is advised for women who are, or are contemplating pregnancy and they should keep their intake under 200 mg per day. Our lifestyle studies at Curtin University showed adverse effects from caffeine consumption in both men and women. For men, fertilization rates were negatively associated with caffeine consumption (P<0.05) as well as IVF-related stress (P<0.005). Furthermore, caffeine negated the beneficial effect of male alcohol consumption, comprising mainly beer, on fertilization. For women, fertilization rates were negatively associated with caffeine consumption (P<0.005) and smoking history in years (P<0.001). However, our studies could not show any effect of caffeine consumption on the chance of pregnancy or miscarriage up to week 12 from either male intake (up to 4495 mg per week) or female intake (up to 2706 mg per week). We conclude that there is likely to be an effect from caffeine on one-Carbon metabolism and future studies need to interrogate the concomitant nutritional intake of B-vitamins and serum homocysteine levels, which can indirectly indicate deficiency or interference with this important metabolic pathway.

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“…The use of 100 µM is slightly above the maximal plasma concentration observed in humans (8-10 mg/L, approx. 50 µM [29]), however it has to be taken into consideration that caffeine is consumed frequently over years and the experimental cell culture setting is a short 24 h incubation, which might be the cause for widely using this concentration in other studies, showing no cytotoxicity and not influencing cellular proliferation [11]. Moreover, it has to be mentioned that the maximum plasma concentration of these compounds might be higher after pharmaceutical interventions than after consumption as a nutrients in a diet.…”

Section: Transcriptional Effects Of Caffeine Theobromine Theophylline Pentoxifylline and Propentofylline In Neuronal Cellsmentioning

confidence: 99%

Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells

Janitschke

Lauer

Bachmann

et al. 2020

IJMS

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Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 and 7. They are widely consumed in nutrition and used as pharmaceuticals. Here we investigate the transcriptional regulation of 83 genes linked to Alzheimer’s disease in the presence of five methylxanthines, including the most prominent naturally occurring methylxanthines—caffeine, theophylline and theobromine—and the synthetic methylxanthines pentoxifylline and propentofylline. Methylxanthine-regulated genes were found in pathways involved in processes including oxidative stress, lipid homeostasis, signal transduction, transcriptional regulation, as well as pathways involved in neuronal function. Interestingly, multivariate analysis revealed different or inverse effects on gene regulation for caffeine compared to the other methylxanthines, which was further substantiated by multiple comparison analysis, pointing out a distinct role for caffeine in gene regulation. Our results not only underline the beneficial effects of methylxanthines in the regulation of genes in neuroblastoma wild-type cells linked to neurodegenerative diseases in general, but also demonstrate that individual methylxanthines like caffeine mediate unique or inverse expression patterns. This suggests that the replacement of single methylxanthines by others could result in unexpected effects, which could not be anticipated by the comparison to other substances in this substance class.

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Kinetic and Dynamic Description of Caffeine

Cited by 39 publications

References 38 publications

Green Coffee Extract Improves Cardiometabolic Parameters and Modulates Gut Microbiota in High-Fat-Diet-Fed ApoE-/- Mice

Green Coffee Extract Improves Cardiometabolic Parameters and Modulates Gut Microbiota in High-Fat-Diet-Fed ApoE-/- Mice

The Effect of Caffeine Consumption on Fertilization and IVF Outcomes: A Review and Presentation of Original Data

Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells

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