The world is facing increasingly more severe water security issues. It has, therefore, become imperative to develop sustainable, eco-friendly water management and recycling techniques. This study assessed the capacity of powdered seeds of Moringa oleifera to improve water quality of effluent from two (2) cassava processing plants in Umudike, Nigeria by measuring the variations in specific physicochemical and microbiological parameters of the samples. The biodegradability indices of the wastewater samples were determined as 0.513 and 0.507 for Plants 1 and 2 respectively indicating samples that were fairly biodegradable and treatable biologically. At the end of the 7-day study, turbidity reduced by 59.6% -63.2% while chemical oxygen demand (COD), biochemical oxygen demand (BOD) and total organic carbon values dropped by 66.6% -74.1%, 86.7% -88.2% and 67.0% -72.6% respectively. Correlation analysis showed a strong positive correlation between BOD 5 and COD for both Plants 1 and 2. The total heterotrophic and coliform bacteria were completely removed by around day 5 of the study. The observed bacterial isolates in the effluent at onset were Escherichia coli, Bacillus sp., Klebsiella sp., Salmonella sp., Streptococcus faecalis, Shigella sp. and Aerobacter aerogenes. This study confirms the efficiency of powdered seeds of M. oleifera in biotreatment of wastewater from cassava processing plants.