Kinetic and thermodynamic studies of sunitinib malate interaction with albumin using surface plasmon resonance and molecular docking methods

Mohammadzadeh-Asl, Saeideh; Jafari‬, Amir Homayoun; Aghanejad, Ayuob; Monirinasab, Hannaneh; Dolatabadi, Jafar Ezzati Nazhad

doi:10.1016/j.microc.2019.104089

Cited by 18 publications

(6 citation statements)

References 31 publications

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“…The results showed that the adsorption capacity of curcumin and ibuprofen as model drugs were 0.02 mg/g and 8 mg/g (Figure 9a,b), respectively. One possible reason is that there was a force interaction between the drug and mannitol, but the force between the curcumin and mannitol was significantly weaker than that between the ibuprofen and mannitol, and the weaker force made most of the drug molecules free and difficult to bind to the adsorbent or carrier [62], which was confirmed by the results of AFM and molecular docking. In addition, another reason might be that the differences in the size and arrangement of drug molecules and the size and shape of porous mannitol particles could lead to differences in the dispersion of drug molecules in porous mannitol pores [63].…”

Section: Adsorption Kinetics and In Vitro Dissolution Behavior 231 Ad...mentioning

confidence: 72%

The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol

Li,

Luo,

et al. 2024

Molecules

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Porous materials are widely used as an effective strategy for the solubilization of insoluble drugs. In order to improve the solubility and bioavailability of low water-solubility drugs, it is necessary to prepare porous materials. Mannitol is one of the most popular excipients in food and drug formulations. In this study, porous mannitol was investigated as a drug carrier for low water solubility drugs. Its fabrication, drug loading, and drug release mechanisms were investigated. Porous mannitol was fabricated using the co-spray–antisolvent process and utilizing polyvinylpyrrolidone K30 (PVP K30) as the template agent. Porous mannitol particles were prepared by changing the proportion of the template agent, spraying the particles with mannitol, and eluting with ethanol in order to regulate their pore structure. In subsequent studies, porous mannitol morphology and characteristics were determined systematically. Furthermore, curcumin and ibuprofen, two poorly water-soluble drugs, were loaded into porous mannitol, and their release profiles were analyzed. The results of the study indicated that porous mannitol can be prepared using PVP K30 as a template and that the amount of template agent can be adjusted in order to control the structure of the porous mannitol. When the template agent was added in amounts of 1%, 3%, and 5%, the mannitol pore size increased by 167.80%, 95.16%, and 163.98%, respectively, compared to raw mannitol. Molecular docking revealed that mannitol and drugs are adsorbents and adhere to each other by force interaction. The cumulative dissolution of curcumin and ibuprofen-loaded porous mannitol reached 69% and 70%, respectively. The release mechanism of curcumin and ibuprofen from drug-loaded mannitol was suitable for the Korsmeyer–Peppas kinetic model. In summary, the co-spray–antisolvent method proved effective in fabricating porous materials rapidly, and porous mannitol had a remarkable effect on drug solubilization. The results obtained are conducive to the development of porous materials.

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Section: Adsorption Kinetics and In Vitro Dissolution Behavior 231 Ad...mentioning

confidence: 72%

The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol

Li,

Luo,

et al. 2024

Molecules

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“…The rate of complex formation per second is denoted by the association rate constant ( k a ), while the number of decayed complexes per second is indicated by the dissociation rate constant ( k d ). And the equilibrium constant ( K D ) reflects the affinity of the ligand for different molecules [55] . The values of k a , k d and K D were calculated using the BI‐Data Analysis Program (version 3.10.5).…”

Section: Resultsmentioning

confidence: 99%

“…And the equilibrium constant (K D ) reflects the affinity of the ligand for different molecules. [55] The values of k a , k d and K D were calculated using the BI-Data Analysis Program (version 3.10.5). The binding analysis of different concentrations (20-300 μM) of rutin and CEWL ZM was studied.…”

Section: Data Analysis and Determination Of Kinetic Constantsmentioning

confidence: 99%

Enhancement of Ligand Immobilization on Gold Surface by Optimizing Monolayer Concentration and Pre‐Concentration Studies for Surface Plasmon Resonance Analysis of Rutin‐Lysozyme Interaction

Türkoğlu

2024

ChemistrySelect

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Surface plasmon resonance (SPR) is a versatile tool for real time monitoring of molecular interactions, providing biophysical data such as affinity and kinetics. Rutin is found in various plants and fruits and is utilized in several industries. Because of its therapeutic and industrial importance, the binding of rutin to one of the major proteins found in blood and saliva, lysozyme (LZM), was investigated to determine the affinity constants of the rutin‐LZM interaction. Chicken egg white lysozyme (CEWLZM) was selected as a model ligand. 11‐mercaptoundecanoic acid (MUA) was chosen for the self‐assembled monolayer (SAM) design on the gold chip surface. After optimizing MUA concentration and pre‐concentration studies to enhance ligand immobilization, optimum MUA concentration in SAM formation, ideal running and coupling buffers, flow rate and ligand concentration were determined to perform SPR analysis. Various concentrations of rutin (20–300 μM) were injected into the SPR for kinetic analysis. The association (ka), dissociation (kd) rate constants, and equilibrium constant (KD) were calculated from the kinetics of the binding curves. SPR binding results indicated that the KD value of rutin‐CEWLZM binding was determined as 80.07±1.22 μM. This study demonstrates the binding affinity of rutin to CEWLZM, offering potential insights for medical and pharmaceutical sciences.

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“…This method has evolved into a potent analytical method for finding NIV in food and animal feed. SPR also offers details on the affinities, specificities, and kinetic characteristics of biomolecular interactions [168]. To concurrently detect NIV and DON in wheat, an SPR-based competitive inhibition immunoassay was created [168].…”

Section: Immunological Techniquesmentioning

confidence: 99%

“…SPR also offers details on the affinities, specificities, and kinetic characteristics of biomolecular interactions [168]. To concurrently detect NIV and DON in wheat, an SPR-based competitive inhibition immunoassay was created [168]. In their research, Kadota et al [167] used a monoclonal antibody that also interacts with NIV and DON.…”

Section: Immunological Techniquesmentioning

confidence: 99%

Nivalenol Mycotoxin Concerns in Foods: An Overview on Occurrence, Impact on Human and Animal Health and Its Detection and Management Strategies

Kumar

Mahato

Gupta

et al. 2022

Toxins

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Mycotoxins are secondary metabolites produced by fungi that infect a wide range of foods worldwide. Nivalenol (NIV), a type B trichothecene produced by numerous Fusarium species, has the ability to infect a variety of foods both in the field and during post-harvest handling and management. NIV is frequently found in cereal and cereal-based goods, and its strong cytotoxicity poses major concerns for both human and animal health. To address these issues, this review briefly overviews the sources, occurrence, chemistry and biosynthesis of NIV. Additionally, a brief overview of several sophisticated detection and management techniques is included, along with the implications of processing and environmental factors on the formation of NIV. This review’s main goal is to offer trustworthy and current information on NIV as a mycotoxin concern in foods, with potential mitigation measures to assure food safety and security.

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Kinetic and thermodynamic studies of sunitinib malate interaction with albumin using surface plasmon resonance and molecular docking methods

Cited by 18 publications

References 31 publications

The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol

The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol

Enhancement of Ligand Immobilization on Gold Surface by Optimizing Monolayer Concentration and Pre‐Concentration Studies for Surface Plasmon Resonance Analysis of Rutin‐Lysozyme Interaction

Nivalenol Mycotoxin Concerns in Foods: An Overview on Occurrence, Impact on Human and Animal Health and Its Detection and Management Strategies

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