In this study, we have successfully fabricated adsorbent from grapefruit peel by microwave method and applied it to CFX antibiotic treatment in water. The structural properties of the material are determined by: FTIR, SEM, BET. That the adsorption performance was best under the following conditions: pH = 4, initial CFX concentration = 80 mg/l, grapefruit peel dose = 0.5 g/L, adsorption time = 20 minutes. The model's experimental data is assessed for the appropriateness by Langmuir, Freundlich, Temkin, D-R, PSO, PFO, Elovivh, Bangham models.