Kinetic characteristics and physicochemical properties of isobornyl phenols with different alkyl substituents in the ortho-position

Evaluation of antiviral activity of terpenophenols and some of their N- and O-derivatives

“…Terpenophenols 1-6, 13-19 and their derivatives 29, 30 were synthesized according to known methods. 8, [16][17][18][19] Hydrochlorides 21-28 were prepared to increase the solubility of previously prepared Mannich bases 6,7, 20 in DMSO. Compounds 13-30 are racemates.…”

“…Compounds 13-30 are racemates. R = 6-Me (13), 5-Me (14), 2,4-Me 2 (15), 2-ОН ( 16), 2-ОН, 4-Me (17), 3-ОН (18), 4-ОН (19) By condensation of substituted isobornylbenzaldehydes with 1-adamantylamine followed by reduction (in situ) of intermediate imines, aminomethyl derivatives containing the 1-adamantyl group at the nitrogen atom were synthesized for the fi rst time; they were also converted into the corresponding hydrochlorides 27 and 28. The synthesis of compound 27 is shown in Scheme 2 as an example.…”

Alkylation of isobornylphenols with styrene in the presence of p-toluenesulfonic acid

“…The kinetic characteristics and physicochemical properties of isobornylphenols with methyl and tert-butyl groups in the ortho-position indicated competing effects of the donor power and steric shielding of the alkyl substituent in the orthoposition with respect to the hydroxy group [9].…”