Kinetic Characteristics of Amino Acid Salt Crystallization in Methanol‐Water System

Abstract

Nucleation and growth mechanisms and kinetics of crystals of an amino acid salt were investigated in a methanol-water system by measuring and evaluating the induction time as a function of the supersaturation ratio and temperature in batch salting out crystallization experiments. Discrimination between the possible crystallization mechanisms, and estimation of the kinetic parameters were carried out using nonlinear parameter identification. The results concerning the growth mechanism obtained were checked additionally by measuring the induction time as a function of number density of seed crystals.

Review: Nucleation in solutions revisited

“…(8) S = s 2 , these values correspond to the s range of 3.0 to 4.7 used by these authors). The induction time at a given S value was determined from recordings of the temporal evolution of the signal of a Ca-ion-selective electrode, a technique which is consistent with the volumetric formula (42). In addition, it was independently established that precipitation occurred by nucleation of many sphere-like crystallites growing at a rate G ∝ (S 1/2 − 1) 1.8 .…”

“…The B values used in Eq. (42) are smaller at higher temperatures and are calculated from Eq. (32) with υ 0 , γ and γ ef treated as independent of T and having the values given in Table 1.…”

Growth kinetics of potassium chloride II—Water–ethanol systems

“…Hence, the influence of organic molecules on the mechanisms of spontaneous nucleation and on the crystal habit of the precipitates thus obtained has been investigated by a number of researchers [1][2][3][4][5][6][7]. Comparatively, much less attention has been devoted to the effect of the cosolvents upon the crystallization mechanisms and growth kinetics of inorganic seed crystals [8].…”