Kinetic Features of Degradation of R-Loops by RNase H1 from Escherichia coli
Aleksandra A. Kuznetsova,
Iurii A. Kosarev,
Nadezhda A. Timofeyeva
et al.
Abstract:R-loops can act as replication fork barriers, creating transcription–replication collisions and inducing replication stress by arresting DNA synthesis, thereby possibly causing aberrant processing and the formation of DNA strand breaks. RNase H1 (RH1) is one of the enzymes that participates in R-loop degradation by cleaving the RNA strand within a hybrid RNA–DNA duplex. In this study, the kinetic features of the interaction of RH1 from Escherichia coli with R-loops of various structures were investigated. It w… Show more
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