Kinetic Investigations on the Hydrogenation of 3-Ketosucrose

Abstract

of the starting materials and the catalyst. A quantitative correlation for the influence of the concentrations is given. Furthermore, the influence of mass transfer processes was considered. Under unfavorable conditions gas liquid mass transfer can be rate-limiting.

Fructansucrase enzymes and sucrose analogues: A new approach for the synthesis of unique fructo-oligosaccharides

“…The biotransformation was optimized and scaled up to give 70% yield of 3-ketosucrose (Stoppok et al 1992). Subsequent chemical steps provide access to a range of products, including a-D-allopyranosyl b-D-fructofuranoside (allosucrose; Timme et al 1998), the corresponding cyanohydrin (Timme et al 2001), oximes, and 3-amino-3-deoxy-a-D-allopyranosyl a-D-fructofuranoside via the classical route of reductive amination (Pietsch et al 1994). Aminoacyl and peptide conjugates were obtained through conventional peptide synthesis with activated and protected amino acids (Figure 3).…”

Regioselective modification of unprotected glycosides

“…The group of Buchholz elaborated on this and optimized this fermentation process to yield 3-ketosucrose 36 in 70% on the kilogram scale. 106 Furthermore, a series of modifications of 3-ketosucrose including the conversion into allosucrose 37, 107 allose, 107 3-amino-3-deoxy-a-Dallopyranosyl b-D-fructofuranoside (38), 108,109 corresponding polymer building blocks (39), 109 surfactants (39), 109 sucrose-amino acid conjugates (39), 108 alkylated sucrose via Grignard-reaction (40) 109 and the cyanohydrin 41 110 could be obtained. The derivatives were synthesized usually without the use of protecting groups in 2-4 steps and could be isolated in good yields.…”