Kinetic Mathematical Modeling of Oxidative Phosphorylation in Cardiomyocyte Mitochondria

Abstract

Oxidative phosphorylation (OXPHOS) is an oxygen-dependent process that consumes catabolized nutrients to produce adenosine triphosphate (ATP) to drive energy-dependent biological processes such as excitation-contraction coupling in cardiomyocytes. In addition to in vivo and in vitro experiments, in silico models are valuable for investigating the underlying mechanisms of OXPHOS and predicting its consequences in both physiological and pathological conditions. Here, we compare several prominent kinetic models of OXPHOS in cardiomyocytes. We examine how their mathematical expressions were derived, how their parameters were obtained, the conditions of their experimental counterparts, and the predictions they generated. We aim to explore the general landscape of energy production mechanisms in cardiomyocytes for future in silico models.

Metabolism, metabolites, and macrophages in cancer

“…In the past, researchers thought that glycolysis was the main source of ATP that maintains tumour cell growth [38]. However, in glycolysis, each glucose molecule produces two ATP molecules, while mitochondrial OXPHOS produces approximately 30 ATP molecules [39]. Therefore, aerobic glycolysis is not the main source of ATP synthesis in tumour cells and many tumours obtain energy through glucose oxidation [40][41][42][43].…”