2002
DOI: 10.1074/jbc.m201947200
|View full text |Cite
|
Sign up to set email alerts
|

Kinetic Mechanism of Human Class IV Alcohol Dehydrogenase Functioning as Retinol Dehydrogenase

Abstract: background Maintaining cognitive function is an important aspect of healthy ageing. In this study, we examined age trajectories of cognitive decline in a large nationally representative sample of older people in England. We explored the factors that influence such decline and whether these differed by gender. Methods Latent growth curve modelling was used to explore age-specific changes, and influences on them, in an 8-year period in memory, executive function, processing speed and global cognitive function am… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

1
23
0

Year Published

2002
2002
2021
2021

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 39 publications
(24 citation statements)
references
References 61 publications
1
23
0
Order By: Relevance
“…The mRNA levels in the airway epithelium of 44 antioxidant-related genes in 4 categories were quantified, including: (i) catalase/superoxide dismutase family; (ii) glutathione metabolism; (iii) redox balance; and (iv) pentose phosphate cycle. Of the 44 antioxidant-related genes assessed, 16 were significantly upregulated in the smokers compared with the nonsmokers, many more than have been previously linked to smoking. There was minimal intra-individual variability in the level of expression of these genes between the right and left lung or over time, indicating that the expression level of the genes assessed in this study represents a repeatable characteristic of the individual.…”
mentioning
confidence: 98%
See 1 more Smart Citation
“…The mRNA levels in the airway epithelium of 44 antioxidant-related genes in 4 categories were quantified, including: (i) catalase/superoxide dismutase family; (ii) glutathione metabolism; (iii) redox balance; and (iv) pentose phosphate cycle. Of the 44 antioxidant-related genes assessed, 16 were significantly upregulated in the smokers compared with the nonsmokers, many more than have been previously linked to smoking. There was minimal intra-individual variability in the level of expression of these genes between the right and left lung or over time, indicating that the expression level of the genes assessed in this study represents a repeatable characteristic of the individual.…”
mentioning
confidence: 98%
“…Among the seven redox balancerelated genes on the HuGeneFL chip, four were observed to be significantly upregulated in the smokers, including alcohol dehydrogenase 7, aldo-keto reductase 1C3, aldoketo reductase 1B1, and thioredoxin reductase 1. Although these enzymes are not classical antioxidants like the enzymes of the glutathione pathway, they are involved in the synthesis of other antioxidants such as retinoic acid and ascorbic acid, as well as in oxidative processes related to the metabolism of tobacco xenobiotics, and thus are involved in the balance between oxidation and antioxidation (16)(17)(18).…”
Section: Upregulation Of Antioxidant-related Genes In the Airway Epitmentioning
confidence: 99%
“…The key enzymes involved in retinoid metabolisms are alcohol and aldehyde dehydrogenases that convert retinols to aldehydes and aldehydes to carboxylic acids, respectively. The first oxidation reaction is catalyzed by a large number of enzymes from the SDR superfamily (6,7) and by classic medium chain alcohol dehydrogenases (8). SDRs are weakly conserved in their primary sequences, with the exception of key residues involved in catalysis, nucleotide recognition, and members of closely related subfamilies.…”
mentioning
confidence: 99%
“…In retinal pigment epithelium (RPE), an unidentified enzyme carries out the isomerization of all-trans-retinol either directly or through an ester intermediate to generate 11-cis-retinol, which can be oxidized to 11-cis-retinal, the visual chromophore (4). Reversible oxidation to retinal can be carried out by several members of the microsomal, short-chain alcohol dehydrogenase family and possibly by class I, III, and IV medium-chain alcohol dehydrogenases (5,6). Oxidation of retinal by retinal dehydrogenase types 1, 2, 3, and 4 generates retinoic acid (RA) (7)(8)(9)(10)(11)(12), which controls development and cellular differentiation via nuclear receptors (13).…”
mentioning
confidence: 99%