Kinetic modelling and residue depletion of drugs in eggs

Hekman, P.; Schefferlie, G. J.

doi:10.1080/00071668.2011.577055

Cited by 22 publications

(11 citation statements)

References 15 publications

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“…Several researchers have tried to explain the distribution between egg white and egg yolk. Some authors investigated possible explanations such as plasma protein binding, lipid solubility, partition coefficient and molecular weight, but no clear correlation between any of these parameters and the preference for one of the egg matrices could be demonstrated (Kan and Petz 2000;Kan 2003;Hekman and Schefferlie 2011). No clear conclusions could be made in our study either.…”

Section: Discussioncontrasting

confidence: 76%

“…Donoghue and Hairston (1999) investigated the possibility of incorporation into egg white during the latter phases of formation. Hekman and Schefferlie (2011) recently presented a physiologically based pharmacokinetic model that describes and predicts drug residue profiles of certain veterinary drugs in eggs based on their plasma kinetics. No plasma concentrations were measured in our study, therefore this model could not be tested using our results.…”

Section: Discussionmentioning

confidence: 99%

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Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Vandenberge¹,

Delezie²,

Huyghebaert³

et al. 2012

Food Additives & Contaminants: Part A

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Recent legislation has addressed the unavoidable carry-over of coccidiostats and histomonostats in feed, which may lead to the presence of residues of these compounds in eggs. In this study, laying hens received cross-contaminated feed at a ratio of 2.5%, 5% and 10% of the therapeutic dose of monensin and lasalocid for broilers. The eggs were collected during the treatment and depletion period and were analysed using liquid chromatography-tandem mass spectrometry. The different egg matrices were separated and analysed during the plateau phase. High lasalocid concentrations, which exceeded the maximum residue level, and low monensin concentrations were found in whole egg. Plateau levels were reached at days 7-9 for lasalocid and at days 3-5 for monensin. For lasalocid, the highest concentrations were measured in egg yolk; residue concentrations in egg white were very low.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Vandenberge¹,

Delezie²,

Huyghebaert³

et al. 2012

Food Additives & Contaminants: Part A

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“…In recent years, we developed a PBPK model (Hekman & Schefferlie, 2011), describing the transport and the time-dependent concentrations of drugs in yolk and albumen in relation to their plasma levels.…”

Section: Introductionmentioning

confidence: 99%

Prediction of the residue levels of drugs in eggs, using physicochemical properties and their influence on passive diffusion processes

Schefferlie

Hekman

2016

Vet Pharm & Therapeutics

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Based on a physiologically based pharmacokinetic model, describing the relationship between the plasma concentration of a drug and its deposition into eggs, general transport constants into yolk and albumen were derived, for a number of compounds, using experimental data from literature. Using only generally accepted concepts in passive diffusion theory, these transport constants were used to derive and calibrate general equations, describing the transport into yolk and albumen, in terms of the physicochemical properties of a drug. It is shown that, in theory, it is possible to calculate/predict the transport constants, using the physicochemical parameters: pKa and plasma protein binding. For a number of sulfonamides, the model was used to predict their distribution between egg yolk and albumen; the outcome was compared to data found in literature. Within this dataset, the lipophilic nature of a drug does not seem to play a major role in explaining the distribution ratio of a drug between albumen and yolk.

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“…Therapeutic doses of these drugs administered to laying hens can lead to the presence of the parent drug and/or its metabolites in eggs. To ensure the safety of these products, only eggs produced after completion of an adequate withdrawal period can be used for human consumption (24). Thus, many authors have studied and established the withdrawal times (WDTs) for several veterinary antimicrobials in eggs, considering the egg as a whole edible product (4,8,23,31) or egg compartments considered as separate matrices (9,27,32,33).…”

mentioning

confidence: 99%

“…Some other authors point out that the distribution of the antimicrobial agents to egg components is a multifactorial phenomenon, which can also involve animal physiology factors, such as organ perfusion, tissue composition, and pH, among others. This complex mix of factors makes it difficult to predict the behavior of drug residues in eggs ( 12,24,25,32).…”

mentioning

confidence: 99%

Withdrawal Times of Oxytetracycline and Tylosin in Eggs of Laying Hens after Oral Administration

Muñoz¹,

Cornejo

Maddaleno³

et al. 2014

Journal of Food Protection

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Antimicrobials administered to laying hens may be distributed into egg white or yolk, indicating the importance of evaluating withdrawal times (WDTs) of the pharmaceutical formulations. In the present study, oxytetracycline and tylosin's WDTs were estimated. The concentration and depletion of these molecules in eggs were linked to their pharmacokinetic and physicochemical properties. Twenty-seven Leghorn hens were used: 12 treated with oxytetracycline, 12 treated with tylosin, and 3 remained as an untreated control group. After completion of therapies, eggs were collected daily and drug concentrations in egg white and yolk were assessed. The yolk was used as the target tissue to evaluate the WDT; the results were 9 and 3 days for oxytetracycline and tylosin, respectively. In particular, oxytetracycline has a good oral bioavailability, a moderate apparent volume of distribution, a molecular weight of 460 g/mol, and is lightly liposoluble. Tylosin, a hydrosoluble compound, with a molecular weight of 916 g/mol, has a low oral bioavailability and a low apparent volume of distribution, too. Present results suggest that the WDTs of the studied antimicrobials are strongly influenced by their oral bioavailability, the distribution, and the molecular weight and solubility, and that these properties also influence the distribution between the egg yolk and white.

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Kinetic modelling and residue depletion of drugs in eggs

Cited by 22 publications

References 15 publications

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Prediction of the residue levels of drugs in eggs, using physicochemical properties and their influence on passive diffusion processes

Withdrawal Times of Oxytetracycline and Tylosin in Eggs of Laying Hens after Oral Administration

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