2014
DOI: 10.1208/s12249-014-0230-8
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Kinetic Modelling for the Assay of Nortriptyline Hydrochloride Using Potassium Permanganate as Oxidant

Abstract: Kinetic methods for accurate determination of nortriptyline hydrochloride have been described. The methods are based on the oxidation of nortriptyline hydrochloride with KMnO4 in acidic and basic media. In acidic medium, the decrease in absorbance at 525.5 nm and in basic medium, the increase in absorbance at 608.5 nm were measured as a function of time. The variables affecting the reactions were carefully investigated and optimised. Kinetic models such as initial rate, rate constant, variable time and fixed t… Show more

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Cited by 8 publications
(2 citation statements)
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“…Being inexpensive, spectrophotometric kinetic methods to determine iodine content in food and dairy products has continuously been used [10,15,[27][28][29]. Kinetic spectrophotometric procedures have also been utilized to determine the analytes such as drugs in different matrices which highlight the importance of kinetic spectrophotometry [30][31][32]. It is an attractive procedure because of its high sensitivity and accuracy without using expensive equipment [6].…”
Section: Introductionmentioning
confidence: 99%
“…Being inexpensive, spectrophotometric kinetic methods to determine iodine content in food and dairy products has continuously been used [10,15,[27][28][29]. Kinetic spectrophotometric procedures have also been utilized to determine the analytes such as drugs in different matrices which highlight the importance of kinetic spectrophotometry [30][31][32]. It is an attractive procedure because of its high sensitivity and accuracy without using expensive equipment [6].…”
Section: Introductionmentioning
confidence: 99%
“…Conventionally, it is a measure of the change in concentration of the chemical species as function of time by using UV-Vis spectrophotometry [12][13][14]. This fact opens a research challenge in the analytical chemistry that addresses the development of simple, inexpensive and accurate methods with a performance as good as sophisticated methods.…”
Section: Introductionmentioning
confidence: 99%