Kinetic pathway of spontaneous vesicle formation

Leng, Jacques; Egelhaaf, Stefan U.; Cates, Michael

doi:10.1209/epl/i2002-00243-1

Cited by 71 publications

(74 citation statements)

References 24 publications

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“…Thus, the final vesicle size is determined kinetically rather than thermodynamically. This agrees with the experiments of Leng et al 14,15 on the micelle-to-vesicle transition in surfactant solutions.…”

Section: A Self-assemblysupporting

confidence: 93%

“…The selfassembly dynamics was studied experimentally by timeresolved scattering techniques ͑light, neutron, and X ray͒. [13][14][15][16][17] Typically, the surfactants are found to aggregate into disklike micelles, which grow and transform into a vesicle when their radius exceeds a critical size. The final vesicle size is probably more controlled by kinetics than by thermodynamics.…”

Section: Introductionmentioning

confidence: 99%

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Dynamics of vesicle self-assembly and dissolution

Noguchi

Gompper

2006

The Journal of Chemical Physics

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The dynamics of membranes is studied on the basis of a particle-based meshless surface model, which was introduced earlier ͓Phys. Rev. E 73, 021903 ͑2006͔͒. The model describes fluid membranes with bending energy and-in the case of membranes with boundaries-line tension. The effects of hydrodynamic interactions are investigated by comparing Brownian dynamics with a particle-based mesoscale solvent simulation ͑multiparticle collision dynamics͒. Particles self-assemble into vesicles via disk-shaped membrane patches. The time evolution of assembly is found to consist of three steps: particle assembly into discoidal clusters, aggregation of clusters into larger membrane patches, and finally vesicle formation. The time dependence of the cluster distribution and the mean cluster size is evaluated and compared with the predictions of Smoluchowski rate equations. On the other hand, when the line tension is suddenly decreased ͑or the temperature is increased͒, vesicles dissolve via pore formation in the membrane. Hydrodynamic interactions are found to speed up the dynamics in both cases. Furthermore, hydrodynamics makes vesicle more spherical in the membrane-closure process.

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Section: A Self-assemblysupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Dynamics of vesicle self-assembly and dissolution

Noguchi

Gompper

2006

The Journal of Chemical Physics

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“…Hereafter we call this process the "mechanism I" (see also Figure 1(a)). Note that the mechanism I is also supported by Monte Carlo simulations [6] or experiments of lipid systems [7,8]. Strictly speaking, the mechanism obtained by the experiments for lipid systems may be different from one for polymer systems.…”

Section: Introductionmentioning

confidence: 71%

Density functional simulation of spontaneous formation of vesicle in block copolymer solutions

Uneyama

2007

The Journal of Chemical Physics

112

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We carry out numerical simulations of vesicle formation based on the density functional theory for block copolymer solutions. It is shown by solving the time evolution equations for concentrations that a polymer vesicle is spontaneously formed from the homogeneous state. The vesicle formation mechanism obtained by our simulation agree with the results of other simulations based on the particle models as well as experiments. By changing parameters such as the volume fraction of polymers or the Flory-Huggins interaction parameter between the hydrophobic subchains and solvents, we can obtain the spherical micelles, cylindrical micelles or bilayer structures, too. We also show that the morphological transition dynamics of the micellar structures can be reproduced by controlling the Flory-Huggins interaction parameter.

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“…It is interesting to note that Monte Carlo simulation and experiments on lipids system are in favor of the first mechanism, suggesting that the vesicle formation mechanism for lipid and polymersomes could be the same [25][26][27].…”

Section: Polymersome Formationmentioning

confidence: 99%

Recent trends in the tuning of polymersomes’ membrane properties

2011

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Abstract. "Polymersomes" are vesicular structures made from the self-assembly of block copolymers. Such structures present outstanding interest for different applications such as micro-or nano-reactor, drug release or can simply be used as tool for understanding basic biological mechanisms. The use of polymersomes in such applications is strongly related to the way their membrane properties are controlled and tuned either by a precise molecular design of the constituting block or by addition of specific components inside the membrane (formulation approaches). Typical membrane properties of polymersomes obtained from the self-assembly of "coil coil" block copolymer since the end of the nineties will be first briefly reviewed and compared to those of their lipidic analogues, named liposomes. Therefore the different approaches able to modulate their permeability, mechanical properties or ability to release loaded drugs, using macromolecular engineering or formulations, are detailed. To conclude, the most recent advances to modulate the polymersomes' properties and systems that appear very promising especially for biomedical application or for the development of complex and bio-mimetic structures are presented.

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Kinetic pathway of spontaneous vesicle formation

Cited by 71 publications

References 24 publications

Dynamics of vesicle self-assembly and dissolution

Dynamics of vesicle self-assembly and dissolution

Density functional simulation of spontaneous formation of vesicle in block copolymer solutions

Recent trends in the tuning of polymersomes’ membrane properties

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