2024
DOI: 10.1021/jacs.4c07103
|View full text |Cite
|
Sign up to set email alerts
|

Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis

Guljannat Ablat,
Neev Lawton,
Ruqaiya Alam
et al.

Abstract: Chemical mutagenesis via dehydroalanine (Dha) is a powerful method to tailor protein structure and function, allowing the site-specific installation of post-translational modifications and non-natural functional groups. Despite the impressive versatility of this method, applications have been limited, as products are formed as epimeric mixtures, whereby the modified amino acid is present as both the desired L-configuration and a roughly equal amount of the undesired D-isomer. Here, we describe a simple remedy … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 54 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?