2017
DOI: 10.5301/jo-n.5000023
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Kinetic Sodium Equation with Built-In Rate of Correction: Aid to Prescribing Therapy for Hyponatremia or Hypernatremia

Abstract: At times, patients overdo the well-meaning advice of avoiding chemotherapy toxicity by excessively hydrating. As for hypernatremia, which is much less common at 2.6%, some etiologies include cancer-related hypercalcemia that induces nephrogenic diabetes insipidus (3). Cancer can also interrupt the hypothalamic-pituitary axis and cause central diabetes insipidus. For non-diabetes insipidus reasons, perhaps having to do with diuretics and chemotherapy, the majority of hypernatremia is hospital-acquired (3). Tubu… Show more

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Cited by 10 publications
(28 citation statements)
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“…105 One of the notable drawbacks of these equations is considering the human body as a closed compartment and not accounting for urinary losses of electrolytes and water. Equations such as the Nguyen-Katz equation 106 or the Chen-Shey equation 107 are more rigorous, as they account for urinary losses. However, these latter equations either presume constant parameters or are retrospective, whereas in reality, urine composition may change abruptly during the course of therapy.…”
Section: Therapy Of Hyponatremia In the Cancer Patientmentioning
confidence: 99%
“…105 One of the notable drawbacks of these equations is considering the human body as a closed compartment and not accounting for urinary losses of electrolytes and water. Equations such as the Nguyen-Katz equation 106 or the Chen-Shey equation 107 are more rigorous, as they account for urinary losses. However, these latter equations either presume constant parameters or are retrospective, whereas in reality, urine composition may change abruptly during the course of therapy.…”
Section: Therapy Of Hyponatremia In the Cancer Patientmentioning
confidence: 99%
“…We (S.C. & J.S.) applied our own Edelman-based equation to prescribe IV fluid therapy to five patients with dysnatremia and came close to reaching our therapeutic targets for their serum sodiums (24).…”
Section: Objections Overruledmentioning
confidence: 97%
“…It may not be completely foolproof, but the general equation is worth adopting now. Lastly, more capable sodium equations exist (20,24,(26)(27)(28)(29)(30), but the A-M…”
Section: Final Thoughtsmentioning
confidence: 99%
“…Hyponatremia, defined as serum sodium <135 mmol/L, is a common electrolyte abnormality affecting up to 46% of patients hospitalized in cancer centers. 58 , 59 …”
Section: Key Findingsmentioning
confidence: 99%
“…This makes the equation practical, allowing a clinician to choose the desired rate of sodium correction that will avoid osmotic demyelination and then calculate the IV fluid rate required to achieve this rate. 58 …”
Section: Key Findingsmentioning
confidence: 99%