Kinetic study and modeling of the Rh-catalyzed hydrosilylation of acetophenone in a batch reactor and in a microreactor

Abstract

The Rh-catalyzed hydrosilylation of acetophenone in the presence of [Rh(CO) 2 (l-Cl)] 2 and [Rh(COD)Cl] 2 complexes, as well as with an in situ addition of nitrogen-containing derivatives of mono-and bicyclic terpenes was investigated in a flow microreactor and in a batch reactor. Kinetic modeling, reaction equilibrium analysis and multi-criteria optimization of the process were applied to compare the performances of the reactors. In general, the highest catalytic activity was reached in the presence of [Rh(COD)Cl] 2 and [Rh(CO) 2 (l-Cl)] 2 without the addition of amines. The best reaction selectivity towards 1-phenylethanol silyl ether with the [Rh(CO) 2 (l-Cl)] 2 complex was observed in the microreactor. The addition of (R)-(-)-cis-MyrtNH 2 and (R)-(?)-BornylNH 2 amines, as well as an increase of the amine-to-rhodium molar ratio significantly decreased the conversion and selectivity in both reactors. In this connection, the [Rh(COD)Cl] 2 complex demonstrated a better catalytic performance in all cases. The application of the flow microreactor promoted another elementary reaction pathway due to micromixing effects.

Kontinuierlich produzieren

“…Für den technischen Einsatz sind Mikro‐ und Millireaktoren interessant. Aktuelle Forschungsarbeiten zeigen Vorteile von kontinuierlichen gegenüber Batch‐Prozessen 14. Besonders herausfordernd ist die Integration von Feststoffkatalysatoren in Mikroreaktoren.…”