Kinetic study of gold nanoparticles synthesized in the presence of chitosan and citric acid

Simeonova, Silviya; Georgiev, Peter; Exner, Kai S.; Mihaylov, Lyuben; Nihtianova, D.; Koynov, Kaloian; Balashev, Konstantin

doi:10.1016/j.colsurfa.2018.02.045

Cited by 28 publications

(27 citation statements)

References 57 publications

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“…The results demonstrated the higher in vitro anticancer potential of synthesized NAR-SFNs than that of free NAR in HeLa cancer cells.Nanomaterials 2020, 10, 718 2 of 17 and aspirin. In attempts to overcome these problems and to allow the clinical applications of this compound in humans, the use of novel drug delivery systems (NDDS) has shown great promise [5][6][7].In order to improve the therapeutic efficiency and bioavailability of drugs, scientists have developed a great variety of NDDS. Among these, synthetic or natural nanocarriers, such as solid lipid nanoparticles [5], polymer-nanoparticles [6] and inorganic nanoparticles [7], have been studied.…”

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confidence: 99%

“…In attempts to overcome these problems and to allow the clinical applications of this compound in humans, the use of novel drug delivery systems (NDDS) has shown great promise [5][6][7].In order to improve the therapeutic efficiency and bioavailability of drugs, scientists have developed a great variety of NDDS. Among these, synthetic or natural nanocarriers, such as solid lipid nanoparticles [5], polymer-nanoparticles [6] and inorganic nanoparticles [7], have been studied. The use of nanoparticles has increased in recent years, due to their unique properties, including their small size and the possibility of targeting cells or tissues, which makes them promising delivery systems for increasing the bioavailability, efficacy and solubility of drugs [8][9][10].…”

mentioning

confidence: 99%

“…Nanomaterials 2020, 10, 718 2 of 17 and aspirin. In attempts to overcome these problems and to allow the clinical applications of this compound in humans, the use of novel drug delivery systems (NDDS) has shown great promise [5][6][7].…”

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confidence: 99%

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Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

et al. 2020

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Naringenin (NAR), a flavonoid present in a variety of fruits, vegetables and herbs, exhibits a wide range of pharmacological effects, including anticancer activity. Nevertheless, its application in cancer therapy is limited due to its low bioavailability at the tumour site because of its poor solubility in water and slow dissolution rate. To improve the therapeutic efficacy of NAR, emergent research is looking into using nanocarriers. Silk fibroin (SF), from the Bombyx mori silkworm, is a biocompatible and biodegradable polymer with excellent mechanical properties and an amphiphilic chemistry that make it a promising candidate as a controlled release drug system. The aim of this work is to synthesize naringenin-loaded silk fibroin nanoparticles (NAR-SFNs) by dissolving the SF in the ionic liquid 1-ethyl-3-methylimidazolium acetate, using high-power ultrasounds and rapid desolvation in methanol followed by the adsorption of NAR. The NAR-SFNs were characterized by dynamic light scattering, Fourier transform infrared spectroscopy and thermogravimetric analysis. The drug loading content and encapsulation efficiency were calculated. The drug release profile best fitted a first order equation. The cytotoxicity effects of free NAR, bare silk fibroin nanoparticles (SFNs) and NAR-SFNs were assessed on HeLa and EA.hy926 cells via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results demonstrated the higher in vitro anticancer potential of synthesized NAR-SFNs than that of free NAR in HeLa cancer cells.

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Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

et al. 2020

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“…is indicates that the process of nucleation occurs in the initial period of GR, and in the future, the predominant growth of the formed particles takes place (Figures 3(a)-3(c)). It is known [36] that the activation energy of the nucleation process is much greater than that of the nanocluster and nanoparticle growth. erefore, the last process has a priority.…”

Section: Advances In Materials Science and Engineeringmentioning

confidence: 99%

Deposition of Gold Nanoparticles via Galvanic Replacement in DMSO and Their Influence on Formation of Silicon Nanostructures

Shepida

Кuntyi

Nichkalo

et al. 2019

Advances in Materials Science and Engineering

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The process of gold nanoparticle (AuNP) precipitation on the silicon (Si) surface by galvanic replacement (GR) in dimethyl sulfoxide (DMSO) solution depending on the concentration of H[AuCl4], temperature, and duration was investigated. It is established that with an increase in the concentration of [AuCl4]− ions (from 2 to 8 mM H[AuCl4]), both the size of AuNPs and their surface coverage density are increased. It is demonstrated that an increase in temperature causes the size of AuNPs to increase from 40 to 80 nm at 40°C to 80–120 and 120–160 nm at 50 and 60°C, respectively. As the duration of the GR process increases, there is a tendency of the particle size growth. Under the studied deposition conditions, the organic aprotic solvent medium contributes to the formation of spherical AuNPs with 2D substrate filling. It is established that the AuNPs deposited on the silicon surface catalyze the process of metal-assisted chemical etching (MacEtch), which makes it possible to obtain Si nanostructures in the form of nanowire arrays.

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“…Indeed, the direct conjugation of amino-functionalized antigenic glycans with pre-formed GNPs has not been reported yet, to the best of our knowledge. This is despite the fact that simple amines, amino acids and peptides [68][69][70][71][72][73][74][75][76][77][78], as well as diethylaminoethyl-dextran [79] and chitosan [80] have been reported to bind to GNPs in a pH-dependent manner as the energy of the Au-N interaction is intermediate between those of Au-S and Au-O [81]. The affinity of different functional groups to the surface of GNPs decreases in the series Au-S > Au-NH 2 > Au-COOH [82], which enables the exchange of citrate ligands with amines.…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

Burygin¹,

Abronina²,

Podvalnyy³

et al. 2020

Beilstein J. Nanotechnol.

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A number of bacterial glycans are specific markers for the detection and the serological identification of microorganisms and are also widely used as antigenic components of vaccines. The use of gold nanoparticles as carriers for glyco-epitopes is becoming an important alternative to the traditional conjugation with proteins and synthetic polymers. In this study, we aimed to prepare and evaluate in vivo glyco-gold nanoparticles (glyco-GNPs) bearing the terminal-branched hexaarabinofuranoside fragment (Ara6) of arabinan domains of lipoarabinomannan and arabinogalactan, which are principal polysaccharides of the cell wall of Mycobacterium tuberculosis, the causative agent of tuberculosis. In particular, we were interested whether the antibodies generated against Ara6-GNPs would recognize the natural saccharides on the cell surface of different mycobacterial strains. Two synthetic Ara6 glycosides with amino-functionalized spacer aglycons differing in length and hydrophilicity were directly conjugated with spherical gold nanoparticles (d = 15 nm) to give two sets of glyco-GNPs, which were used for the immunization of rabbits. Dot assays revealed cross-reactions between the two obtained antisera with the hexaarabinofuranoside and the 2-aminoethyl aglycon used for the preparation of glyco-GNPs. Both antisera contained high titers of antibodies specific for Mycobacteria as shown by enzyme-linked immunosorbent assay using M. bovis and M. smegmatis cells as antigens while there was only a weak response to M. phlei cells and no interaction with E. coli cells. The results obtained suggest that glyco-GNPs are promising agents for the generation of anti-mycobacterial antibodies.

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Kinetic study of gold nanoparticles synthesized in the presence of chitosan and citric acid

Cited by 28 publications

References 57 publications

Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

Deposition of Gold Nanoparticles via Galvanic Replacement in DMSO and Their Influence on Formation of Silicon Nanostructures

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

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