Kinetic study of low density lipoprotein oxidation by copper

Ghaffari, Mohammad Ali; Ghiasvand, Taibeh

doi:10.1007/s12291-010-0006-1

Cited by 17 publications

(13 citation statements)

References 22 publications

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“…Second, Cu is a powerful catalyst of LDL oxidation in vitro (O'Leary et al, 1992; Patel et al, 1997). When Cu ions are added to LDL, they can react with the lipid hydroperoxides within the LDL to generate peroxyl and alkoxyl radicals that continue LDL oxidation, which is important in the early phases of atherogenesis (Esterbauer et al, 1992, Ghaffari & Ghiasvand, 2010Gieseg et al, 2003;Patel et al, 1997). It is also reported that homocysteine, a risk factor for cardiovascular disease, interacts with Cu to produce oxidant stress (Dong et al, 2013;Kang, 2011;Linder & Hazegh-Azam, 1996).…”

Section: Publication Bias and Sensitivity Analysismentioning

confidence: 99%

Association between copper levels and myocardial infarction: a meta-analysis

Chen

Lei

2015

Inhalation Toxicology

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Section: Publication Bias and Sensitivity Analysismentioning

confidence: 99%

Association between copper levels and myocardial infarction: a meta-analysis

Chen

Lei

2015

Inhalation Toxicology

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“…[22] Previous investigation showed that the amount of hydroperoxides accumulated decreased at a CuSO 4 concentration above 20 mmol/L. [23] This may be due to the possible decomposition of unstable hydroperoxides during incubation. To avoid any variation due to decomposition, we chose to use a CuSO 4 concentration equal to 20 mmol/L.…”

Section: Inhibition Effect Of Blueberry Anthocyanins Against Human Ldmentioning

confidence: 98%

Low‐density lipoprotein oxidation inhibition by anthocyanins of wild blueberries

et al. 2017

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The use of natural compounds to prevent oxidative damage in biological systems is becoming increasingly popular. Blueberries have been of specific interest because of their high antioxidant capacity. Anthocyanins were extracted from berries of Vaccinium angustifolium Aiton and Vaccinium myrtilloides Michaux at 79 °C in acidified ethanol with phosphoric acid as a solvent using a liquid/solid ratio of 10. Extracted anthocyanins were purified on a C‐18 silica‐packed column and analyzed by HPLC coupled to electrospray ionization mass spectrometry. Of the six common anthocyanidins, five were identified in the extracts, namely delphinidin, cyanidin, peonidin, petunidin, and malvidin, while pelargonidin was not found. The free radical scavenging effects of anthocyanins were evaluated using N,N‐dimethyl‐p‐phenylenediamine method as well as their potential to mitigate in vitro low‐density lipoprotein (LDL) oxidative damage. After 6 h of incubation, the oxidation products formation such as that of conjugated dienes, trienes, and hexanal was inhibited up to 60 %. Based on these data, we concluded that anthocyanins from V. angustifolium and V. myrtilloides of Quebec possess the ability to inhibit in vitro LDL oxidation.

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“…It is involved in fat metabolism, in particular of lipoproteins: Marginal copper deficiency has been reported as a potential etiologic factor in diseases characterized by disrupted fat metabolism such as nonalcoholic fatty liver disease . The oxidation of low‐density lipoproteins (LDLs) is thought to play a significant role in atherosclerosis: Low copper status is associated with reduced activity of superoxide dismutase (SOD), which favors LDL oxidations.…”

Section: Copper Metabolismmentioning

confidence: 99%

Copper Deficiency: Causes, Manifestations, and Treatment

et al. 2019

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Background: The metabolism of the essential trace element copper remains incompletely understood and, until recently, nearly ignored in acute medicine. Menkes disease was for long the only known copper deficiency condition, but several case reports and investigations conducted over the last 2 decades have shown that deficiency is more frequent than previously suspected, with devastating individual consequences and potential public health consequences. The copper needs in healthy individuals are 0.9 mg/d, which translates to 0.3 mg/d intravenously in parenteral nutrition; the present review aims at gathering actual knowledge. Method and results: A review of literature was conducted in PubMed and Cochrane systematic reviews to identify the most recent information about copper deficiency and generate a narrative review. Copper deficiency has hereditary and acquired origins, the latter being the most frequent. Clinical manifestations are nonspecific but affect all organs and systems, particularly the hematologic (anemia) and the neurologic (myeloneuropathy) systems. Deficiency also affects the cardiovascular, cutaneous, and immune systems. Severe copper deficiency due to reduced absorption after bariatric bypass surgery has become frequent. Conclusion: Deficiency is more frequent than previously recognized, probably because of changing nutrition patterns but also because of some treatments that have become very common such as bypass bariatric surgery and, in acute medicine, prolonged continuous renal replacement therapy. The patients may present with severe hematologic and neurologic complications that go untreated because copper deficiency was not considered in the differential diagnosis: These complications often need active intravenous repletion with doses 4-8 times the usual nutrition recommendations. (Nutr Clin Pract. 2019;34:504-513)

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Kinetic study of low density lipoprotein oxidation by copper

Abstract: Oxidation of Low Density Lipoprotein (LDL) is regarded as a key event in the development

Cited by 17 publications

References 22 publications

Association between copper levels and myocardial infarction: a meta-analysis

Association between copper levels and myocardial infarction: a meta-analysis

Low‐density lipoprotein oxidation inhibition by anthocyanins of wild blueberries

Copper Deficiency: Causes, Manifestations, and Treatment

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