Kinetic study of proton-bound dimer formation using ion mobility spectrometry

Jazan, Elham; Tabrizchi, Mahmoud

doi:10.1016/j.chemphys.2008.11.001

Cited by 23 publications

(30 citation statements)

References 25 publications

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“…The molecule can participate in different reactions, the most important being the association reactions with neutral molecules 9, 80 , the formation of monomers MH + , (M-H) - or MO 2 - , and the formation of dimers M 2 H + or trimers M 3 H + at high concentrations of analyte. Further hydration reactions will lead to the formation ion clusters, e.g.…”

Section: Sections Of An Ion Mobility Spectrometermentioning

confidence: 99%

Review on Ion Mobility Spectrometry. Part 1: current instrumentation

Cumeras

Figueras

Davis

et al. 2015

Analyst

385

312

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Ion Mobility Spectrometry (IMS) is a widely used and ‘well-known’ technique of ion separation in gaseous phase based on the differences of ion mobilities under an electric field. All IMS instruments operate with an electric field that provides space separation, but some IMS instruments also operate with a drift gas flow which provides also a temporal separation. In this review we will summarize the current IMS instrumentation. IMS techniques have received an increased interest as new instrumentation has become available to be coupled with mass spectrometry (MS). For each of the eight types of IMS instruments reviewed it is mentioned whether they can be hyphenated with MS and whether they are commercially available. Finally, out of the described devices, the six most-consolidated ones are compared. The current review article is followed by a companion review article which details the IMS hyphenated techniques (mainly gas chromatography and mass spectrometry) and the factors that make the data from an IMS device change as function of device parameters and sampling conditions. These reviews will provide the reader with an insightful view of the main characteristics and aspects of the IMS technique.

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Section: Sections Of An Ion Mobility Spectrometermentioning

confidence: 99%

Review on Ion Mobility Spectrometry. Part 1: current instrumentation

Cumeras

Figueras

Davis

et al. 2015

Analyst

385

312

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“…Significantly, only a limited experimental record, obtained largely at subambient pressures using selected ion flow tube mass spectrometry, exists on rate constants specifically for hydrated protons, and these studies were from Kebarle et al, Bohme et al, , Castleman et al, , and others , are also relevant. Rate constants for formation of proton bound dimers are known only from studies with ion mobility spectrometry …”

Section: Introductionmentioning

confidence: 99%

Parametric Sensitivity in a Generalized Model for Atmospheric Pressure Chemical Ionization Reactions

Lattouf

Anttalainen

Kotiaho

et al. 2021

J. Am. Soc. Mass Spectrom.

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Gas phase reactions between hydrated protons H+(H2O) n and a substance M, as seen in atmospheric pressure chemical ionization (APCI) with mass spectrometry (MS) and ion mobility spectrometry (IMS), were modeled computationally using initial amounts of [M] and [H+(H2O) n ], rate constants k 1 to form protonated monomer (MH+(H2O) x ) and k 2 to form proton bound dimer (M2H+(H2O) z ), and diffusion constants. At 1 × 1010 cm–3 (0.4 ppb) for [H+(H2O) n ] and vapor concentrations for M from 10 ppb to 10 ppm, a maximum signal was reached at 4.5 μs to 4.6 ms for MH+(H2O) x and 7.8 μs to 46 ms for M2H+(H2O) z . Maximum yield for protonated monomer for a reaction time of 1 ms was ∼40% for k 1 from 10–11 to 10–8 cm3·s–1, for k 2/k 1 = 0.8, and specific values of [M]. This model demonstrates that ion distributions could be shifted from [M2H+(H2O) z ] to [MH+(H2O) x ] using excessive levels of [H+(H2O) n ], even for [M] > 10 ppb, as commonly found in APCI MS and IMS measurements. Ion losses by collisions on surfaces were insignificant with losses of <0.5% for protonated monomer and <0.1% for proton bound dimer of dimethyl methylphosphonate (DMMP) at 5 ms. In this model, ion production in an APCI environment is treated over ranges of parameters important in mass spectrometric measurements. The models establish a foundation for detailed computations on response with mixtures of neutral substances.

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“…Their main subjects are phenomena related to the formation of ions from various substances, as well as the charge transport in gases. Standard drift tube ion mobility spectrometers (DT IMS) can be used in studies that allow estimation of the rate constants of ion–molecular reactions [ 5 ], as well as the thermodynamic parameters of these processes [ 6 , 7 , 8 ]. In studies of the kinetics and thermodynamics of ionization, the processes taking place in the drift region are most often considered.…”

Section: Introductionmentioning

confidence: 99%

“…The analysis of the time dependence of the ionic current for these sections allows for the determination of kinetic constants [ 5 , 9 , 10 ]. When the lifetime of product ions formed as a result of reactions taking place in the drift region is much shorter than the characteristic drift time, the peak position depends on the concentration of the sample introduced into the drift gas [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Studies on the Processes of Electron Capture and Clustering of Benzyl Chloride by Ion Mobility Spectrometry

2021

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This paper presents the results of the study on the course of the benzyl chloride (BzCl) ionization process in a drift tube ion mobility spectrometer (DT IMS) in which nitrogen was used as the carrier gas. BzCl ionization follows the dissociative electron capture mechanism. The chloride ions produced in this process take part in the formation of cluster ions. Using DT IMS allows for estimation of the value of the electron attachment rate for BzCl and the equilibrium constant for the cluster ion formation. The basic experimental method used in this work was to analyze drift time spectra obtained for the introduction of the sample to the spectrometer with the drift gas. The theoretical interpretation of the results is based on the mathematical description of the ion transport. This description takes into account the phenomenon of diffusion, as well as the processes of formation and dissociation of ionic clusters occurring during the movement of ions in the drift section.

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Kinetic study of proton-bound dimer formation using ion mobility spectrometry

Cited by 23 publications

References 25 publications

Review on Ion Mobility Spectrometry. Part 1: current instrumentation

Review on Ion Mobility Spectrometry. Part 1: current instrumentation

Parametric Sensitivity in a Generalized Model for Atmospheric Pressure Chemical Ionization Reactions

Studies on the Processes of Electron Capture and Clustering of Benzyl Chloride by Ion Mobility Spectrometry

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