Kinetic Study of the Antioxidant Activity of Pyrroloquinolinequinol (PQQH<sub>2</sub>, a Reduced Form of Pyrroloquinolinequinone) in Micellar Solution

Ouchi, Aya; Nakano, Masahiko; Nagaoka, Shin‐ichi; Mukai, Kazuo

doi:10.1021/jf802197d

Cited by 51 publications

(63 citation statements)

References 43 publications

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“…Now our findings ascertain that PQQ has the potential to regulate PTU induced adverse effects / hypothyroidism. The possible mechanism of its efficacy to ameliorate PTU induced oxidative stress could be its strong antioxidant properties, as suggested in some previous studies, in which the free radical scavenging activity of PQQ has been clearly shown (Ouchi et al, 2009;Misra et al, 2012). Whatever may be the mechanism of action, from our present findings it is clearly evident that PQQ has the potential to ameliorate PTU induced oxidative stress and it may work against hypothyroidism, although for human therapy point of view, further investigation is required.…”

Section: Discussionsupporting

confidence: 72%

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Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Kumar¹

2013

IOSR-JPBS

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Section: Discussionsupporting

confidence: 72%

“…(Hamagishi et al, 1990;Smidt et al, 1991;Aizenman et al, 1992;Bishop et al, 1994;Jensen et al, 1994;Ouchi et al, 2009;Xiong et al, 2011). Despite all these beneficial actions of PQQ, no attempt was made so far by any worker to evaluate its role in the regulation on the oxidative damage in hypothyroidic conditions.…”

Section: Introductionmentioning

confidence: 99%

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Kumar¹

2013

IOSR-JPBS

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“…This substance, initially identified as a coenzyme necessary for certain oxidation-reduction reactions and cell signaling pathways, has recently become of interest as a potentially critical coenzyme in mammals. [14][15][16][17][18][25][26][27][28][29] The importance of PQQ in mammalian health has been reported based on its omission from chemically defined diets, resulting in a wide range of systemic responses, including growth impairment, compromised immune responsiveness, and abnormal reproductive performance in mouse and rat experimental models. 11-13-13,17,18 In the immune system, PQQ deficiency is associated with a reduction in interleukin (IL)-2 level and decreased Tand B-cell sensitivity to mitogens 12 .…”

Section: Discussionmentioning

confidence: 99%

Influence of Adding Pyrroloquinoline Quinone to Parenteral Nutrition on Gut‐Associated Lymphoid Tissue

Omata

Fukatsu

Murakoshi

et al. 2011

J Parenter Enteral Nutr

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Background: Experimental intravenous (IV) parenteral nutrition (PN) diminishes gut‐associated lymphoid tissue (GALT) cell number and function. PN solution cannot maintain GALT at the same level as a normal diet, even when delivered intragastrically (IG). Previous studies demonstrated pyrroloquinoline quinone (PQQ)–deficient mice to be less immunologically responsive. Because standard (STD) PN solution lacks PQQ, PQQ supplementation may prevent PN‐induced GALT changes. This study was designed to determine the influence of adding PQQ to PN on GALT. Methods: In experiment 1, mice (n = 32) were randomized to chow, IV‐STD‐PN, and IV‐PQQ‐PN groups. The chow group was fed chow with the same caloric content as PN. The IV‐STD‐PN group received STD‐PN solution, whereas the IV‐PQQ‐PN group was given PQQ (3 mcg/d)–enriched PN by the IV route. After 5 days of feeding, lymphocytes were isolated from the Peyer's patch (PPs), intraepithelial space (IE), and lamina propria (LP) of the small intestine. GALT lymphocyte number and phenotype (αβTCR+, γδTCR+, CD4+, CD8+, B220+ cells) and intestinal immunoglobulin A (IgA) level were determined. In experiment 2, mice (n = 28) were randomized to IG‐STD‐PN or IG‐PQQ‐PN group. After IG nutrition supports, GALT mass and function were determined as in experiment 1. Results: The IV‐PQQ‐PN group showed increased PP lymphocyte number and PP CD8+ cell number compared with the IV‐STD PN group. The IG‐PQQ‐PN group had significantly greater PP lymphocyte number and PP CD4+ cell numbers than the IG‐STD‐PN group. Neither IV nor IG PQQ treatment raised IgA level. Conclusions: PQQ added to PN partly restores GALT mass, although its effects on GALT function remain unclear.

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confidence: 99%

Effects of Pyrroloquinoline Quinone Disodium Salt Intake on the Serum Cholesterol Levels of Healthy Japanese Adults

Nakano

Kawasaki²,

Suzuki³

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound, and has a strong anti-oxidant capacity (1,2). Trace amounts of PQQ are present in everyday foods and beverages (3) and in the organs and tissues of humans and rats (4). The nutritional importance of PQQ was suggested after a study on rats showed poor growth, osteolathyrism, and friable skin due to a lack of PQQ (5). In addition, several studies in humans have suggested that PQQ plays a role in cognitive improvement (6, 7) and has anti-stress effects (8). A recent study reported that dietary PQQ alters indicators of inflammation and mitochondrial-related metabolism in human subjects (9).Owing to its strong anti-oxidative properties, PQQ is likely to protect mitochondria against damage from reactive oxygen species. Aerobic respiration in the mitochondria leads to the production of reactive oxygen species, which in turn, leads to the induction of lipid peroxidation and the inactivation of lipid metabolism (10, 11) through a deterioration of the mitochondrial energy production cycle. Therefore, the protection of mitochondria from oxidative stress may maintain normal metabolism in mitochondria. AMP-activated protein kinase (AMPK) that accelerates catabolism, i.e. the production of ATP, through the generation of mitochondria, activation of the glycolytic pathway, or glucose capture, is activated following PQQ ingestion in animal studies (12,13). A previous study in rats fed a PQQ-depleted diet reported that PQQ treatment led to an increase in the number of mitochondria in cells and a normalization of elevated triglyceride (TG) levels in circulating blood (13). It is well known that to maintain serum lipid levels at normal range is important, as excessive lipid levels are regarded as a risk factor for various lifestyle-related diseases. Although similar effects are to be expected in humans, to date, to the best of our knowledge, there is only one study on the relationship between PQQ and lipid metabolism in healthy young humans with the normal range of blood lipid levels (9). In the paper, the blood lipid levels remained within the normal range after taking PQQ. The primary purpose of our study was to examine the effects of continuous PQQ treatment for 12 wk on human lipid levels in a randomized, doubleblinded, placebo-controlled trial. The volunteers in this study were healthy Japanese adults with normal to moderately high TG levels including those who had normal to high low-density lipoprotein cholesterol (LDL-chol) levels. Summary Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound that has a strong anti-oxidant capacity. A previous study in rats fed a PQQ-depleted diet showed that elevated levels of serum triglyceride (TG) decreased after PQQ supplementation. However, there is only one study reporting the effects of PQQ on serum lipid levels, such as those of TG and cholesterol, in humans. In this study, the effects of PQQ disodium salt (BioPQQ TM ) on serum TG and cholesterol levels in humans after 6 and 12 wk of treatment at an ora...

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Kinetic Study of the Antioxidant Activity of Pyrroloquinolinequinol (PQQH₂, a Reduced Form of Pyrroloquinolinequinone) in Micellar Solution

Cited by 51 publications

References 43 publications

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Influence of Adding Pyrroloquinoline Quinone to Parenteral Nutrition on Gut‐Associated Lymphoid Tissue

Effects of Pyrroloquinoline Quinone Disodium Salt Intake on the Serum Cholesterol Levels of Healthy Japanese Adults

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Kinetic Study of the Antioxidant Activity of Pyrroloquinolinequinol (PQQH2, a Reduced Form of Pyrroloquinolinequinone) in Micellar Solution

Cited by 51 publications

References 43 publications

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Influence of Adding Pyrroloquinoline Quinone to Parenteral Nutrition on Gut‐Associated Lymphoid Tissue

Effects of Pyrroloquinoline Quinone Disodium Salt Intake on the Serum Cholesterol Levels of Healthy Japanese Adults

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Kinetic Study of the Antioxidant Activity of Pyrroloquinolinequinol (PQQH₂, a Reduced Form of Pyrroloquinolinequinone) in Micellar Solution