Kinetic study of the thermal decomposition of adenosine

Tanaka, Yasuhito

doi:10.1016/0040-6031(89)85097-x

Thermochimica Acta

1989

DOI: 10.1016/0040-6031(89)85097-x

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Kinetic study of the thermal decomposition of adenosine

Yasuhito Tanaka

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Cited by 2 publications

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The conformational structure of adenosine molecules, isolated in low-temperature Ar matrices

Ivanov

Rubin

Egupov

et al. 2015

Low Temperature Physics

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FTIR spectra of adenosine (Ado) molecules, isolated in low-temperature matrices, are obtained in the infrared range of 3800–400 cm−1, with a resolution of 0.3. MP2 and DT/B3LYP quantum-mechanical methods are used to calculate the population of major structural Ado isomers. It is shown that Ado can withstand prolonged evaporation at a temperature of 465 K without thermal decomposition. The structure five major conformers that are fixed in Ar matrices at 6 K, are established. Ado anti-conformers with intramolecular hydrogen bonds O2′H-N3, are found. The population of these anti-conformers is more than one and a half times less than the syn-conformer population having the intramolecular hydrogen bond O5′H-N3. In low-temperature matrices, the majority of the dominant conformers are fixed with a C2′-endo ribose ring structure. Similar to 2′-deoxyadenosine (dA), Ado conformers with intramolecular hydrogen bonds O3′H-O5 or O5′H-O3 were not found.

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The conformational structure of adenosine molecules, isolated in low-temperature Ar matrices

Ivanov

Rubin

Egupov

et al. 2015

Low Temperature Physics

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Molecular structure and vibrational spectra of isolated nucleosides at low temperatures (Review article)

Ivanov

Stepanian

2021

Low Temperature Physics

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The application of various action spectroscopy and absorption spectroscopy methods for studying the structure of biological molecules and their constituent fragments in an isolated state is considered. The main attention is paid to the results achieved in the study of the nucleosides which are the structural units of DNA and RNA. It has been demonstrated that modern low-temperature spectroscopy methods allow registration the vibrational spectra of isolated nucleosides in neutral or ionized form. It was shown that most of the nucleosides can be converted into the gas phase by prolonged evaporation from the Knudsen cell without thermal decomposition. Cooling molecules to cryogenic temperatures plays an important role in these studies. The conformational equilibrium of the gas phase between syn and anti subsets of nucleosides is maintained due to fast cooling when frozen in inert matrices. Within these subsets, interconversion processes between conformers can occur during cooling if the conformers are separated by low energy barriers. In inert gas matrices at 6 K, subsets of the syn-conformers of deoxyribonucleosides are mainly frozen with the C2′-endo structure of the deoxyribose ring. The structures of molecular ions of nucleosides are very different from their neutral forms. In particular protonation leads to the domination of the enol forms of thymidine, as well as syn-conformations of adenosine, stabilized by the intramolecular hydrogen bond N3H+•••O5.

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Kinetic study of the thermal decomposition of adenosine

Cited by 2 publications

References 6 publications

The conformational structure of adenosine molecules, isolated in low-temperature Ar matrices

The conformational structure of adenosine molecules, isolated in low-temperature Ar matrices

Molecular structure and vibrational spectra of isolated nucleosides at low temperatures (Review article)

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