Kinetic study on pyridinolysis of aryl benzenesulfonates: factors governing regioselectivity and reaction mechanism

Abstract

A kinetic study is reported for reactions of 2,4-dinitrophenyl X-substituted-benzenesulfonates (1a-1f) and Y-substituted-phenyl benzenesulfonates (2a-2f) with Z-substituted-pyridines. The reactions proceed through S‒O and C‒O bond scissions competitively. The Yukawa-Tsuno plot for the reactions of 1a-1f with 4-oxypyridine (S‒O bond fission) exhibits an excellent linearity. The Brønsted-type plot for the reactions of 2,4-dinitrophenyl benzenesulfonate (1d) with pyridines (S‒O bond fission) is also linear with βnuc = 0.62. The Brønsted-type plot for the reactions of 2a-2f with 4-oxypyridines (S‒O bond fission) is linear with βlg= ‒1.17. Thus, the reactions have been concluded to proceed through a concerted mechanism, in which leaving-group expulsion is significantly more advanced than bond formation between the electrophilic center and nucleophile at the transition state. The Hammett plot for the reactions of 1a-1f with 4-oxypyridine (C‒O bond fission) exhibits scattered points with ρX= 0.98. The Brønsted-type plot for the reactions of 1d with Z-substituted-pyridines (C‒O bond fission) results in an excellent linear correlation with βnuc = 0.38. Thus, the reactions (C‒O bond fission) have been concluded to proceed through a stepwise mechanism with a Meisenheimer complex, in which expulsion of the leaving group occurs after the rate-determining step. Factors governing regioselectivity and reaction mechanism are discussed.