Kinetically Controlled Dendritic Mesoporous Silica Nanoparticles: From Dahlia- to Pomegranate-like Structures by Micelle Filling

Abstract

A unique dynamic structural transition from large-pore dendritic mesoporous silica nanoparticles (DMSNs) with a dahlia-like morphology to pomegranate-like mesoporous silica nanoparticles with small mesopores is reported. The structural evolution is accompanied by gradually filling the preformed dendritic large pores with silica-coated micelles, providing a series of DMSNs with kinetically controlled dual mesoporosity. The heterogeneous porous structure of DMSNs demonstrates advantages in the co-loading of two positively charged drug molecules, showing promising potential in cellular delivery applications.

Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation

“…[11] An umber of elegant synthetic strategies has been used for the preparation of DMSN,i ncluding biphase stratification, [12] emulsion/microemulsion templating, [13] anion based micelles swelling, [14] dynamic polystyrene templating, [15] counterions enabled micelle aggregation [16] and assembly of cone-like subunits.I ti sn oted that silica-coated composite micelles,s wollen micelles and lamellar structures are usually involved simultaneously as building blocks for the formation of DMSN, [17] which could reduce the surface area and pore volumes of the final product. [18] In contrast, nanostructures constructed mainly by lamellar building blocks such as silica vesicles and their supra-assembly possess high pore volume and in turn enable high payload. [19] However,itis difficult to synthesize silica vesicles as dispersed nanoparticles with uniform particle size and pore opening size.T od ate, there is no report to assemble mesoporous silica nanoparticles solely by lamellar building blocks,w hich are expected to be ideal candidates for enzyme delivery applications due to high pore volume,large surface area and pore/opening sizes as well as uniform particle sizes.…”

“…A number of elegant synthetic strategies has been used for the preparation of DMSN, including biphase stratification, [12] emulsion/microemulsion templating, [13] anion based micelles swelling, [14] dynamic polystyrene templating, [15] counterions enabled micelle aggregation [16] and assembly of cone‐like subunits. It is noted that silica‐coated composite micelles, swollen micelles and lamellar structures are usually involved simultaneously as building blocks for the formation of DMSN, [17] which could reduce the surface area and pore volumes of the final product [18] . In contrast, nanostructures constructed mainly by lamellar building blocks such as silica vesicles and their supra‐assembly possess high pore volume and in turn enable high payload [19] .…”

Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation

“…[11] An umber of elegant synthetic strategies has been used for the preparation of DMSN,i ncluding biphase stratification, [12] emulsion/microemulsion templating, [13] anion based micelles swelling, [14] dynamic polystyrene templating, [15] counterions enabled micelle aggregation [16] and assembly of cone-like subunits.I ti sn oted that silica-coated composite micelles,s wollen micelles and lamellar structures are usually involved simultaneously as building blocks for the formation of DMSN, [17] which could reduce the surface area and pore volumes of the final product. [18] In contrast, nanostructures constructed mainly by lamellar building blocks such as silica vesicles and their supra-assembly possess high pore volume and in turn enable high payload. [19] However,itis difficult to synthesize silica vesicles as dispersed nanoparticles with uniform particle size and pore opening size.T od ate, there is no report to assemble mesoporous silica nanoparticles solely by lamellar building blocks,w hich are expected to be ideal candidates for enzyme delivery applications due to high pore volume,large surface area and pore/opening sizes as well as uniform particle sizes.…”

Multifunctionalized Mesostructured Silica Nanoparticles Containing Mn2 Complex for Improved Catalase-Mimicking Activity in Water

“…Even if the pores are less open than in pristine stellate nanoparticles [ 33 ], the pore size distribution of the present dual-functionalized nanoparticles remains large and centered at a larger value than a single micelle would template (ca. 7 nm instead of 3 nm) ( Figures S4–S7, ESI ) [ 33 , 35 , 36 ]. Indeed, a close look to the external contour of the nanoparticle reveals a marked roughness of 10 to 15 nm, close to that of stellate nanoparticles, although in absence of any radial aspect expected for this morphology, placing these nanoparticles in an intermediate state between stellate and raspberry.…”