Kinetics and Mechanism of Cerium(IV) Oxidation of Fosfomycin Disodium Salt: An Antibiotic Drug in Acid Perchlorate Solutions

Jattinagoudar, Laxmi N.; Byadagi, Kirthi S.; Nandibewoor, Sharanappa T.; Chimatadar, Shivamurti A.

doi:10.1080/15533174.2013.862684

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Cerium(IV) is a powerful one electron oxidizing agent in acid media [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Oxidation by cerium(IV) in sulfuric acid solutions have conclusively been established [5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Oxidation by cerium(IV) in sulfuric acid solutions have conclusively been established [5][6][7][8][9][10][11][12][13]. Nevertheless, little reports on cerium(IV) oxidation in perchloric acid solutions [14][15][16][17][18][19], probably due to presence of dimers and polymers of cerium(IV) in such solutions [19]. However, the reactions of cerium(IV) in perchloric acid medium proceed much faster than those in sulfuric acid medium.…”

Section: Introductionmentioning

confidence: 99%

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Kinetics and Mechanistic Study of Oxidation of Pyridine Derivative by Cerium(IV) in Aqueous Perchloric Acid

Fawzy¹,

Zaafarany

Tirkistani³

et al. 2016

AJPC

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The kinetics of oxidation of N, N-dimethyl-N'-(pyridin-2-yl) formamidine (Py-F) by cerium(IV) was studied spectrophotometrically in aqueous perchloric acid solutions at a constant ionic strength of 1.0 mol dm-3 and at 20°C. The reaction showed first order dependence with respect to [Ce(IV)] and less than unit order with respect to [Py-F]. The reaction exhibited negative fractional-first order kinetics with respect to [H + ]. The rate of reaction was not significantly affected by variation of either ionic strength or dielectric constant of the reaction medium. Addition of cerium(III) product did not affect the reaction rate. A suitable mechanistic scheme for the oxidation reaction has been proposed. The final oxidation products were identified as 2-aminopyridine, dimethylamine and carbon dioxide. The activation parameters have been evaluated and discussed. The rate law associated with the reaction mechanism was derived.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kinetics and Mechanistic Study of Oxidation of Pyridine Derivative by Cerium(IV) in Aqueous Perchloric Acid

Fawzy¹,

Zaafarany

Tirkistani³

et al. 2016

AJPC

View full text Add to dashboard Cite

show abstract

“…Cerium(IV) is a powerful one electron oxidizing agent in acid media [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Oxidation by cerium(IV) in sulfuric acid solutions have conclusively been established [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Oxidation by cerium(IV) in sulfuric acid solutions have conclusively been established [1][2][3][4][5][6][7][8][9]. Nevertheless, little reports on cerium(IV) oxidation in perchloric acid solutions [10][11][12][13][14][15][16][17], probably due to presence of dimers and polymers of cerium(IV) in such solutions [17]. However, the reactions of cerium(IV) in perchloric acid medium proceed much faster than those in sulfuric acid medium.…”

Section: Introductionmentioning

confidence: 99%

Oxidation of Formamidines by Cerium(IV) in Aqueous Perchlorate Solutions: A Kinetics and Mechanistic Approach

Fawzy

Zaafarany

Althagafi

et al. 2016

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The kinetics of oxidation of one of the formamidine derivatives, namely, methylaminopyrazole formamidine (MAPF) by cerium(IV) has been investigated in aqueous perchlorate solutions at a constant ionic strength of 1.2 mol dm-3 and at 25°C. The progress of the reaction was followed spectrophotometrically. The reaction exhibited a first order kinetics with respect to [Ce(IV)], whereas the order with respect to [MAPF] was found to be less than unity. The reaction rate decreased with the increase in acid concentration with a negative less than unit order. The rate of reaction was not affected by increasing either ionic strength or dielectric constant of the medium. Furthermore, addition of cerium(III) product did not affect the reaction rate. The plausible oxidation mechanism involves formation of an intermediate complex between MAPF substrate and the kinetically active species of cerium(IV) in a pre-equilibrium step which decomposes in the slow step to give free radical derived from the substrate and Ce(III). The free radical is attacked by another Ce(IV) species to yield the final oxidation products which were identified by spectral and chemical analyses as methylaminopyrazole, dimethylamine and carbon dioxide. The activation parameters have been evaluated and discussed. The rate law associated with the reaction mechanism was derived.

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Relative kinetic stability towards redox decomposition of cerium(IV) complexes with some organic compounds

Voskresenskaya

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2020

Monatsh Chem

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Kinetics and Mechanism of Cerium(IV) Oxidation of Fosfomycin Disodium Salt: An Antibiotic Drug in Acid Perchlorate Solutions

Cited by 6 publications

References 14 publications

Kinetics and Mechanistic Study of Oxidation of Pyridine Derivative by Cerium(IV) in Aqueous Perchloric Acid

Kinetics and Mechanistic Study of Oxidation of Pyridine Derivative by Cerium(IV) in Aqueous Perchloric Acid

Oxidation of Formamidines by Cerium(IV) in Aqueous Perchlorate Solutions: A Kinetics and Mechanistic Approach

Relative kinetic stability towards redox decomposition of cerium(IV) complexes with some organic compounds

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