Kinetics and Mechanism of Oxidation of Paracetamol by Thallic Perchlorate in Acid Medium

Ruthenium(III) catalyzed oxidation of paracetamol by chloramine‐T in aqueous alkaline medium – A kinetic and mechanistic pathway

“…The estimation of paracetamol by titrimetric and spectrophotometric has been performed in studies. [18][19][20][21][22] As the oxidation studies are scanty, it is for this reason that we were prompted to undertake the kinetics of oxidation of the paracetamol (heretofore written as PCM) with chloramine-T to know more about its pattern of reactivity and to perceive the logical conditions in such a manner that paracetamol can be determined quantitatively in solutions by this oxidant in aqueous alkaline medium from the following viewpoints: First, the analytical facts regarding the speciation of chloramine-T species in an alkaline medium can be achieved. Second, the pattern of reactivity of ruthenium(III) as a catalyst can also be understood for a proper proposition of the reaction mechanism.…”

“…Due to its clinical effects as an inhibitor are still indefinite, new findings are needed in the mode of action of paracetamol which is an advancement in physiological and pharmacological points of view. The estimation of paracetamol by titrimetric and spectrophotometric has been performed in studies 18–22 . As the oxidation studies are scanty, it is for this reason that we were prompted to undertake the kinetics of oxidation of the paracetamol (heretofore written as PCM) with chloramine‐T to know more about its pattern of reactivity and to perceive the logical conditions in such a manner that paracetamol can be determined quantitatively in solutions by this oxidant in aqueous alkaline medium from the following viewpoints: First, the analytical facts regarding the speciation of chloramine‐T species in an alkaline medium can be achieved.…”

Osmium(VIII) Catalyzed Oxidative Degradation of Paracetamol by Chloramine-T in Aqueous Alkaline Medium - A Computational Screening and Mechanistic Pathway

“…This drug has not, yet been exploited kinetically [9] so far as its oxidation chemistry is concerned. The Scantiness of such oxidation studies [10,11] has prompted us to undertake the oxidation kinetics of paracetamol (heretofore written as PCM) with chloramine-T to know more about its pattern of reactivity in aqueous alkaline medium from the following viewpoints: rst the chloramine-T species speciation in the alkaline medium can be achieved and secondly the pattern of reactivity of osmium(VIII) as a catalyst can also be understood for a proper proposition of the reaction mechanism. Oxidation reactions are useful in synthesis process of pharmaceutical drugs and organic compounds.…”