Kinetics and Mechanism of the Ligand Substitution Reaction of the Di-μ-hydroxobis(bipyridyl)dipalladium(II) Ion with some Bio-relevant Ligands

Mallick, Subhasis; Bera, Biplab K.; Karmakar, Parnajyoti; Mondal, Subala; Mandal, Arup; Ghosh, Aditi

doi:10.1007/s10953-011-9659-5

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…The study of 1-phenyl piperazine complexes was performed because the piperazine ring may undergo stacking interactions with the sugar group of DNA. This will enhance complex formation with DNA subunits, which is a principal target in the chemotherapy of tumors [11]. The latter effect is similar to that reported for carboplatin, where the stacking interaction between the cyclobutane ring and the sugar group is part of the increased antitumor activity [12].…”

Section: Introductionsupporting

confidence: 65%

Complex formation reactions and equilibrium studies of mixed ligand complexes of diaqua (1-Phenyl piperazine)(Palladium)(II) with some biologically relevant ligands.

Shoukry

2012

International Journal of Basic and Applied Sciences

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With the purpose of the search of new antitumor metal complexes, the complex-formation reactions of2+ (Phenpip = 1-Phenylpiperazine) with some selected bio-relevant ligands, containing different functional groups (amino acids, peptides, DNA constituents and dicarboxylic acids) were investigated. Stoichiometry and stability constants for the complexes formed are reported. The results show the formation of 1 : 1 complexes with amino acids and dicarboxylic acids. The effect of chelate ring size of the dicarboxylic acid complexes on their stability constants was examined. Peptides form both 1 : 1 complexes and the corresponding deprotonated amide species. Structural effects of the peptide on the amide deprotonation were investigated. DNA pyrimidinic constituents, such as uracil, uridine, thymidine and thymine, form 1 : 1 and 1 : 2 complexes, whereas purinic constituents, such as inosine, inosine 5´-monophosphate (5-IMP) form only 1 : 1 complexes. The stability constant of the complexes formed in solution were determined and the binding centers of the ligands were assigned. The concentration distribution diagrams of the complexes were evaluated

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Section: Introductionsupporting

confidence: 65%

Complex formation reactions and equilibrium studies of mixed ligand complexes of diaqua (1-Phenyl piperazine)(Palladium)(II) with some biologically relevant ligands.

Shoukry

2012

International Journal of Basic and Applied Sciences

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“…In addition, it supports the hypothesis of a drug reservoir mechanism in which the palladium-sulphur adduct is an intermediate for palladium binding to DNA. 37…”

Section: Discussionmentioning

confidence: 99%

Kinetics and mechanism for the substitution reactions of monoaquamonochloro-(piperazine) palladium (II) complex with L-methionine and thiourea in aqueous solution

Shoukry

2013

J Chem Sci

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The interaction of the palladium(II) complex [Pd(Pip)Cl(H 2 O)] + , where Pip is piperazine, with the sulphur donor nucleophiles; L-methionine (L-Met), and thiourea (tu) was studied under pseudo-first-order conditions as a function of nucleophile concentration and temperature, using UV-Visible spectrophotometric and stopped-flow techniques. Two consecutive reaction steps were observed for the substitution process with L-methionine. For the substitution with thiourea, a third reaction step, the displacement of the labilized amine, as a result of the strong trans-effect of thiourea ligand was observed. 1 HNMR spectroscopy was used to follow the substitution of the ligand by thiourea. The activation parameters for all reactions studied suggest an associative substitution mechanism.

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“…The k 1 (second-order rate constant) value was obtained from the slope of line k obs (1) (2) (Fig. 4), which was independent of [H 2 salen].…”

Section: Kinetics Studymentioning

confidence: 99%

“…The ligand exchange reaction Ni(salpn) with H 2 salen was found to be a two-step process (biphasic reaction) as described by the experimental rate constants k obs (1) and k obs (2). The k obs (1), is depended on the concentration of the H 2 salen ligand, according to Equation 8.…”

Section: Proposed Mechanismmentioning

confidence: 99%

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Kinetics and mechanism of the ligand exchange reaction between tetradentate schiff base N,N'-ethylen-bis (salicylaldimine) and Ni(N,N'-propylen-bis(salicylaldimine))

Vafazadeh¹,

Bagheri²

2015

S.Afr.j.chem

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Visible spectrophotometry is used to study the kinetics of ligand exchange in the system Ni(salpn)/H 2 salen with or without triethylamine (NEt 3 ) and H 2 O in dimethylformamide (DMF) solvent at 25 ± 0.1 °C and 0.01 M NaNO 3 [H 2 salen and H 2 salpn are N,N'-ethylen-bis(salicylaldimine) and N,N'-propylen-bis(salicylaldimine), respectively]. It was found that the reaction rate is of the first-order with respect to Ni(salpn). In addition, the effect of NEt 3 and H 2 O on the rate of the reaction was examined. The rate of the ligand exchange reaction was accelerated by adding NEt 3 to the reaction mixture. However, the ligand exchange rate was not changed by adding H 2 O to the mixture reaction. The effects of NEt 3 and H 2 O on the ligand exchange rate show that deprotonation/protonation of the H 2 salen ligand and anionic form of H 2 salen is important. On the basis of these results, the reaction mechanism is discussed.

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Kinetics and Mechanism of the Ligand Substitution Reaction of the Di-μ-hydroxobis(bipyridyl)dipalladium(II) Ion with some Bio-relevant Ligands

Cited by 5 publications

References 25 publications

Complex formation reactions and equilibrium studies of mixed ligand complexes of diaqua (1-Phenyl piperazine)(Palladium)(II) with some biologically relevant ligands.

Complex formation reactions and equilibrium studies of mixed ligand complexes of diaqua (1-Phenyl piperazine)(Palladium)(II) with some biologically relevant ligands.

Kinetics and mechanism for the substitution reactions of monoaquamonochloro-(piperazine) palladium (II) complex with L-methionine and thiourea in aqueous solution

Kinetics and mechanism of the ligand exchange reaction between tetradentate schiff base N,N'-ethylen-bis (salicylaldimine) and Ni(N,N'-propylen-bis(salicylaldimine))

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