Kinetics and mechanism of uncatalyzed and silver(I)-catalyzed oxidation of l-histidine by hexachloroplatinate(IV) in acid medium

A Comparative Kinetic Study of Silver(I)-Catalyzed Oxidations of Alanine and Valine by Platinum (IV) in Perchloric and Sulfuric Acids Solutions

“…The observed enhancement of the oxidation rates upon increasing acids concentration with the less than unit order dependences suggests [39] that the protonated forms of the amino acids may be considered as the kinetically reactive species in the rate-determining step, which play the main role in the reactions kinetics. The less than unit order dependences with respect to the concentrations of the amino acids suggests formation of intermediate complexes between amino acids and Ag I catalyst as reported earlier [17,18,21] owing to the availability of the electron pairs on both oxygen atom of the carboxylate group and nitrogen atom of the amine group in the amino acids. Within the protolytic amino acids systems, the carboxylate and amine groups may act as nucleophiles, depending on pH of the medium.…”

“…Platinum (IV) complexes have increased interest in the last decades due to their remarkable anticancer properties [24][25][26][27]. Kinetic studies on the oxidation of inorganic and organic substrates using one of the platinum (IV) complexes such as hexachloroplatinate (IV) complex, [PtCl 6 ] 2-, are scarce and limited to a few cases [15][16][17][18][19][20][21][28][29][30][31], in which [PtCl 6 ] 2-may behave as one or two electron oxidant, depending upon the substrate and experimental conditions. The knowledge of the reactivity of platinum (IV) compounds towards their reduction by potential bioreductants such as alanine and valine may be important for understanding the mechanism of where antitumor activity as well as for designing new compounds with the least side effect.…”

“…Transition metal ions have been widely employed as homogenous catalysts for oxidation of organic and inorganic substrates [12][13][14][15][16][17][18][19][20][21][22] by different reaction pathways such as formation of complexes with the reactants, oxidation of a substrate, or the formation of free radicals [32]. Kinetic investigations on the oxidation of amino acids catalyzed by different metal ions are an important field of chemistry due to the role played by metals in biological systems.…”

Base-Catalyzed Oxidation of Aminotriazole Derivative by Permanganate Ion in Aqueous Alkaline Medium: A Kinetic Study

“…On the other hand, the enhancement of oxidation rate upon addition of small amounts of alkali-metal ion catalysts, have interpreted [30][31][32][33][34] on the basis of specific effects of metal ions in terms of bridging which facilitates electron transfer in redox systems, while Wahl [35,36] and his co-workers have interpreted specific effects in terms of complex formation.…”

Ruthenium(III)-Catalyzed Oxidation of Vanillin by Anticancer Hexachloroplatinate(IV) Complex in Perchloric Acid Solutions: A Kinetic Study

“…Platinum(IV) complex in the form of hexachloroplatinate (IV) (HCP), [PtCl 6 ] 2− , has been used to oxidize a limited number of inorganic [12][13][14][15][16] and organic [17][18][19][20][21][22][23][24][25][26][27][28][29] compounds in different media. Knowledge of the reactivity of Pt(IV) compounds and their reduction by potential bioreductants, like vanillin, is important for understanding the mechanism of antitumor activity as well as for designing new compounds with fewer side effects.…”