Kinetics and Mechanistic Studies on Oxidation of Levocarnitine by Bromamine‐T in HCl Medium Catalyzed by Ru(III)

Ramachandrappa, R.; Iyengar, Pushpa; Usha, Joseph

doi:10.1155/2013/574626

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Ramachandrappa and co-workers performed a kinetic study of the oxidation of levocarnitine (LC) by bromamine-T using RuCl 3 as the catalyst in HCl at 303 K (Scheme 71 ). 98 The reaction was found to exhibit first-order kinetics with respect to [BAT] 0 , whereas a fractional dependence on both [LC] 0 and [H + ] was recorded. A detailed study of the reaction kinetics established the reaction stoichiometry as 1:1.…”

Section: Organic Transformations Using Bromamine-tmentioning

confidence: 96%

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

Kashyap¹,

Phukan²

2023

Synlett

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Bromamine-T (BAT) is a distinguished member of a special class of compounds called organic haloamines, possessing oxidising properties. It can act as the source of halonium ions, hypohalite species, and N-anions, along with the display of basic as well as nucleophilic properties. Bromamine-T finds wide application as an efficient reagent for various organic transformations such as aminobromination, amination, oxidation etc., under mild conditions with minimum toxicity. Moreover, due to its immense biological significance, this reagent is piquing the interest of numerous researchers.

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Section: Organic Transformations Using Bromamine-tmentioning

confidence: 96%

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

Kashyap¹,

Phukan²

2023

Synlett

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“…Contemporary studies using BAT mainly concern the examination of drugs oxidation mechanisms in biological systems (drugs used, for instance, in the treatment of allergies and diabetes) [6][7][8][9][10][11]. Also, research work is conducted on the possibility of obtaining aziridine compounds from olefins (used, among other things, in the production of pharmaceuticals and optically active compounds) using BAT as a source of nitrogen [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A macromolecular N-bromosulphonamide as a heterogeneous oxidant in acidic media

Ciechanowska

Kociołek‐Balawejder

2015

Polym. Bull.

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Styrene-divinylbenzene copolymer containing N-bromosulphonamide groups as sodium salt, [P]-SO 2 NBrNa, can be viewed as a high molecular weight redox polymer mimicking its low molecular weight analogue: Bromamine-T. The stability of this copolymer in acidic media has not been studied in detail to date. This paper reports on studies of the reaction between the copolymer and aqueous FeSO 4 solution conducted in a series of batch and column experiments. It was found that pH \3.0 results in transition of active bromine from -SO 2 NBr -groups to the solution, followed by oxidation of Fe 2? ions to Fe 3? ions by elemental bromine. In reaction media of pH [3.0, active bromine remains bound to the functional groups, facilitating application of this copolymer as an effective oxidant in column processes running in weakly acidic reaction media. Results of the present work provide evidence that -SO 2 NBr -functional groups of the copolymer can stably exist in acidic form which is in contrast to the behaviour of the low molecular weight analogue (N-bromo-p-toluenesulphonic acid does not occur as a pure chemical compound).

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“…Redox reactions have been the subject of detailed mechanistic and kinetic studies as they are most commonly encountered in chemical analysis. Investigation reveals that oxidation of compounds using other oxidants have been carried out [3][4][5][6][7][8][9][10]. Organic haloamines resemble hypohalites in their oxidative behaviour, but are more stable than hypohalites and are developing rapidly as oxidants, disinfectants and antiseptics.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Oxidation of Propranolol by Sodium – N – Chloro – pToluene Sulphonamide in NaOH medium. A Mechanistic Study

Ramachandrappa¹

2012

iosrphr

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Propranolol is used for treating high blood pressure, heart pain, abnormal rhythms of the heart and some neurologic conditions. Kinetics and oxidation of Propranolol (PPL) ((RS)-1-(1-methylethylamino)-3-(1-naphthyloxy)propan-2-ol) by sodium-N-chlorop-toluenesulphonamide (Chloramine-T or CAT) in NaOH medium at 298K have been studied. The rate was first order in [CAT] o, fractional order in [PPL] and zero order in [OH-]. Addition of p-toluenesulphonamide, NaCl and NaBr did not affect the rate of the reaction. Variation in ionic strength did not affect the rate of the reaction indicating that nonionic species are involved in the rate limiting step. Dielectric effect of the medium showed positive effect. Rate increased with increase in temperature from 288K to 318K. From the linear Arrhenius plot, activation parameters were computed. Addition of reaction mixture to aqueous acrylonitrile solution did not initiate polymerization, showing the absence of free radicals species. Oxidation products were identified. TsNClNa, the reactive species oxidizes the substrate. Based on kinetic results, reaction stoichiometry and oxidation products, a suitable mechanism have been proposed.

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Kinetics and Mechanistic Studies on Oxidation of Levocarnitine by Bromamine‐T in HCl Medium Catalyzed by Ru(III)

Cited by 3 publications

References 18 publications

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

A macromolecular N-bromosulphonamide as a heterogeneous oxidant in acidic media

Kinetics of Oxidation of Propranolol by Sodium – N – Chloro – pToluene Sulphonamide in NaOH medium. A Mechanistic Study

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