Kinetics and mechanistic study of oxidation of paracetamol: an accelerated catalytic approach

Abstract

In the present paper, a simple, and novel method for the abatement of paracetamol (PA) in aqueous system into environmental friendly compound benzoquinone at 308 K has been described, and was accelerated by simple, and inexpensive catalyst Cu(II)/Ni(II). A comparative assessment between Cu(II) and Ni(II)catalyzed, abatement of PA by CAT was performed. It has been determined that there are very little change in rate of reaction for both Cu(II)/Ni(II) catalyzed degradation of PA. All the kinetics parameters, i.e. the effect of change in concentrations of chloramine-T (CAT), sodium hydroxide, paracetamol, catalyst, added p-toluenesulfonamide, electrolyte etc. have been studied, and measured carefully. Reaction had been studied in the range of temperature 303-323 K. On the basis of kinetic data obtained a satisfactory mechanism has been proposed. And it was deduced that, presently used process was a tenable technique for the degradation of PA. Main abatement product was confirmed by GC-MS analysis technique.

Ruthenium(III) catalyzed oxidation of paracetamol by chloramine‐T in aqueous alkaline medium – A kinetic and mechanistic pathway

“…The estimation of paracetamol by titrimetric and spectrophotometric has been performed in studies. [18][19][20][21][22] As the oxidation studies are scanty, it is for this reason that we were prompted to undertake the kinetics of oxidation of the paracetamol (heretofore written as PCM) with chloramine-T to know more about its pattern of reactivity and to perceive the logical conditions in such a manner that paracetamol can be determined quantitatively in solutions by this oxidant in aqueous alkaline medium from the following viewpoints: First, the analytical facts regarding the speciation of chloramine-T species in an alkaline medium can be achieved. Second, the pattern of reactivity of ruthenium(III) as a catalyst can also be understood for a proper proposition of the reaction mechanism.…”

“…Due to its clinical effects as an inhibitor are still indefinite, new findings are needed in the mode of action of paracetamol which is an advancement in physiological and pharmacological points of view. The estimation of paracetamol by titrimetric and spectrophotometric has been performed in studies 18–22 . As the oxidation studies are scanty, it is for this reason that we were prompted to undertake the kinetics of oxidation of the paracetamol (heretofore written as PCM) with chloramine‐T to know more about its pattern of reactivity and to perceive the logical conditions in such a manner that paracetamol can be determined quantitatively in solutions by this oxidant in aqueous alkaline medium from the following viewpoints: First, the analytical facts regarding the speciation of chloramine‐T species in an alkaline medium can be achieved.…”

Multifunctional properties of acetaminophen immobilized polymer nanohybrid composites

“…Jenny et al, reported the hydrogen bonding between methacrylic acid and amide functionality of acetaminophen have been synthesized via thermally initiated free radical polymerization [12]. This common drug, which is both the analgesic and anti-pyretic crystallizes into its most stable monoclinic form and a less stable thermodynamically favorable orthorhombic form [13,14]. Chen et al [15], have reported, high performance electrochemical sensing behavior of acetaminophen on SWCNTs and graphene sheet based hybrid films.…”