Kinetics of 1H→13C NMR cross-polarization in polymorphs and solvates of the antipsychotic drug olanzapine

Thermal Study of Anhydrous and Hydrated Forms of Olanzapine

“…Recently it was summarizes that the drug exists in three different anhydrides, three dehydrated forms, a higher hydrate and an undisclosed number of solvates and mixed solvates [4]. The structure of some of these forms have been described by a number of papers using sophisticated analysis such as FT-Raman, infrared and near infrared [3,6], X ray diffraction [1,7]; 13 C and 15 N CP/MAS NMR [4] and 1 H- 13 C NMR spectroscopy [8]. In front of the simplicity of thermal analysis to study the solid state of the drugs, this technique, as investigation tool of the olanzapine solid state, was employed only in few papers [9,10].…”

1H‐13C cross‐polarization kinetics to probe hydration‐dependent organic components of bone extracellular matrix

“…The frequency of oscillation is dependent on the I*S dipolar interaction. [39] In general, for isolated S-I n clusters in a powder sample under MAS but without extensive molecular motion, the kinetics of the CP signal intensity I(t) is then described by…”

Structural studies of two capsaicinoids: dihydrocapsaicin and nonivamide. 13C and 15N MAS NMR supported by genetic algorithm and GIAO DFT calculations

“…For some crystalline compounds, T H 1r values were signicantly higher, for example olanzapine form II (T 1r ¼ N). 16 The molecular dynamics of solid b-carotene were studied by means of 13 C CPMAS NMR. 17 The T CP average value of 0.79 ms was found for methine carbons and 0.65-0.78 ms for methylene carbons, which indicated that these groups must be in a exible molecular fragment.…”