Kinetics of bile acid metabolism in experimental blind loop syndrome.

Abstract

SUMMARY In an experimental model of the contaminated small bowel syndrome, Eriksson's washout technique was used to study bile salt metabolism. Bile salt secretion rate was increased from 204.7 + SD 365 5,mol/100 g body weight/24 h to 329.9 + 146.6, pool size from 33.4 + 5.4,umol/100 g BW to 42.5 + 7.2, and biliary flow from 6.6 + 1[72 ml/100 g BW/24 h to 8.4 + 2.l. Detailed analysis of the washout curves gave indirect evidence of a short-circuit jejunohepatic shunt in the model contaminated small bowel syndrome. Parameters of this shunt were calculated with 9 1 ,mol/ 100 g BW for 'short-circuit' pool size and 13.8 for its circulation frequency.

Biliary lipid secretion in cholesterol gallstone disease. The effect of cholecystectomy and obesity.

“…(55). Within the small intestine, proximal reabsorption of conjugated secondary bile salts may cause shortcircuiting, such as the jejunohepatic shunting associated with bacterial overgrowth (56).…”

A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings

“…For example, preclinical data suggest that bacterial overgrowth in the small intestine may be associated with an increase in BA pool size. 42 At the same time, a decrease in colonic deconjugation or dehydroxylation efficiency was predicted to shift BA composition from secondary to primary species, which has been observed in subjects treated with antibiotics. 43 Finally, in the present study, we performed a theoretical exercise invoking simulations of colonic and systemic BA levels, using a range of parameter values for FXR activation and transintestinal BA flux, to mimic BA malabsorption conditions.…”

“…This function should be modified to ensure daily BA synthesis equal to CA synthesis constant ksyn CA , based on daily CA production. To do so, the area under daily C4 dynamics should be equal to 0, which can be achieved by using equation 42, as follows: (42) Where b ba fgf19 is a parameter that ensures AUC 0À24 (C4)¼0.…”