1994
DOI: 10.1016/0926-6917(94)90067-1
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Kinetics of Cd2+ in plasma, liver and kidneys after single intravenous injection of Cd-metallothionein-II

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1994
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Cited by 5 publications
(10 citation statements)
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“…We determined the activities of LAP and NAG in the kidneys to assess the extent of renal injury; LAP is a marker enzyme for brush-border membranes, 9,10 and NAG a marker enzyme for lysosomes in the proximal tubules. 14,15 Although Cd administration decreased LAP and NAG activities, histopathological examination showed viritually no injury to the kidneys.…”
Section: Discussionmentioning
confidence: 99%
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“…We determined the activities of LAP and NAG in the kidneys to assess the extent of renal injury; LAP is a marker enzyme for brush-border membranes, 9,10 and NAG a marker enzyme for lysosomes in the proximal tubules. 14,15 Although Cd administration decreased LAP and NAG activities, histopathological examination showed viritually no injury to the kidneys.…”
Section: Discussionmentioning
confidence: 99%
“…9 Leucine aminopeptidase (LAP) and N-acetyl--dglucosaminidase (NAG) were determined in the renal homogenates by the methods of Oya et al 19 and Horak et al, 20 respectively. Besides these determinations, Cd, at various concentrations, was added to the reaction mixtures for LAP and NAG, and the effects of Cd on these enzymatic activities were investigated with the renal homogenates obtained from the non-treated rats.…”
Section: Analytical Proceduresmentioning
confidence: 99%
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“…Salts of ionized Cd are absorbed in the duodenum; in addition, complexes of Cd with plant metallothioneins (MT) and phytochelatins (PC) may be absorbed in the colon after liberation by bacteria [6]. In the bloodstream, 2 of 15 Cd is bound to red blood cells, albumin, glutathione (GSH), sulfur-containing amino acids, MT, and PC [6][7][8][9][10]. In the liver, hepatocytes take up Cd not bound to MT [10], synthesize MT in response to the metal, and store complexes of CdMT.…”
Section: Introductionmentioning
confidence: 99%