Saturation parameters and absorption characteristics of N2F4 at 10.6 μm is studied using an intense 1.5 ns pump pulse and a low cw CO2 laser probe. It is found that, for short-pulse interaction, a four-level model describe satisfactorily the experimental results at pressure up to 120 Torr. The main parameters of the model are a rotational–rotational exchange constant of 47 ns Torr, a fundamental radiative cross section of 1×10−16 cm2, a contribution of 1/60 of the ground state population to absorption and a residual absorption coefficient equal to 20% of the small signal absorption at low pressure.