Kinetics of Cortisol in Health and Liver Disease

Weinges, K. F.; Fell, Patrick J.; I, Ehrhardt; Ehrhardt, M.

doi:10.1530/acta.0.067s158

Acta Endocrinologica

1971

DOI: 10.1530/acta.0.067s158

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Kinetics of Cortisol in Health and Liver Disease

K. F. Weinges¹,

Patrick J. Fell²,

Ehrhardt I³

et al.

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1975

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Pharmacokinetics ? Uses and abuses

Fell¹,

Stevens²

1975

Eur J Clin Pharmacol

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It is apparent from studying recent articles on pharmacokinetics that a number of misunderstandings exist, both about the design of experiments and the analysis of results. The purpose of this paper is to outline many of the common pitfalls associated with the design of experiments and also the limitations upon the analysis of results. The paper describes mathematical, laboratory and clinical aspects which must be examined in designing a protocol for pharmacokinetic experiments. Simulated data is presented to demonstrate the dangers of using standard computer programs for parameter estimation. Even when convergence is obtained the answers may be dependent on the method employed. A mathematical model is of little use unless a reasonable amount of good, accurate data is obtained.

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Pharmacokinetics ? Uses and abuses

Fell¹,

Stevens²

1975

Eur J Clin Pharmacol

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show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Kinetics of Cortisol in Health and Liver Disease

Cited by 1 publication

References 0 publications

Pharmacokinetics ? Uses and abuses

Pharmacokinetics ? Uses and abuses

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