Kinetics of dissolution and growth of calcium fluoride and effects of phosphate

Christoffersen, J.; Christoffersen, Margaret R.; Kibalczyc, W.; Perdok, W. G.

doi:10.3109/00016358809004784

Cited by 103 publications

(75 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The dissolution of CaF2 releases free fluoride ions, contributing significantly to the protection of tooth mineral exposed to the oral fluid. Phosphate was known to inhibit the dissolution of CaF2, but phosphate-containing CaF2 dissolves faster than CaF2 at comparable undersaturation (Christoffersen et al, 1988). '9F MAS-NMR has become widely used in studies on the chemical environment of F-ions in the structure of synthetic apatites and biomineral (Kreinbrink et al, 1990;Code et al, 1992).…”

Section: Fluoride In Apatite Structurementioning

confidence: 99%

The Effect of Fluoride On Apatite Structure and Growth

Aoba

1997

Critical Reviews in Oral Biology & Medicine

189

126

View full text Add to dashboard Cite

Fluoride participates in many aspects of calcium phosphate formation in vivo and has enormous effects on the process and on the nature and properties of formed mineral. The most well-documented effect of fluoride is that this ion substitutes for a column hydroxyl in the apatite structure, giving rise to a reduction of crystal volume and a concomitant increase in structural stability. In the process of enamel mineralization during amelogenesis (a unique model for the cell-mediated formation of well-crystallized carbonatoapatite), free fluoride ions in the fluid phase are supposed to accelerate the hydrolysis of acidic precursor(s) and increase the driving force for the growth of apatitic mineral. Once fluoride is incorporated into the enamel mineral, the ion likely affects the subsequent mineralization process by reducing the solubility of the mineral and thereby modulating the ionic composition in the fluid surrounding the mineral, and enhancing the matrix protein-mineral interaction. But excess fluoride leads to anomalous enamel formation by retarding tissue maturation. It is worth noting that enameloid/enamel minerals found in vertebrate teeth have a wide range of CO3 and fluoride substitutions. In the evolutionary process from elasmobranch through teleost enameloid to mammalian enamel, the biosystems appear to develop regulatory functions for limiting the fluoridation of the formed mineral, but this development is accompanied by an increase of carbonate substitution or defects in the mineral. In research on the cariostatic effect of fluoride, considerable emphasis is placed on the roles of free fluoride ions (i.e., preventing the dissolution and accelerating the kinetics of remineralization) in the oral fluid bathing tooth mineral. Fluoride also has been used for the treatment of osteoporosis, but much still remains to be learned about maximizing the benefit and minimizing the risk of fluoride when used as a public health measure.

show abstract

Section: Fluoride In Apatite Structurementioning

confidence: 99%

The Effect of Fluoride On Apatite Structure and Growth

Aoba

1997

Critical Reviews in Oral Biology & Medicine

189

126

View full text Add to dashboard Cite

show abstract

“…Saxegaard and Rølla [1988], using SEM, observed that the globules induced from topical fluoride treatment consisted of microcrystals. Since phosphate is also released from the mineral during CaF 2 formation, phosphate is incorporated in the CaF 2 lattice structure [Christoffersen et al, 1988]. This 'phosphate-contaminated-calcium fluoride' is more soluble than pure calcium fluoride.…”

Section: Calcium Fluoride Formationmentioning

confidence: 99%

CaF<sub>2</sub> Formation: Cariostatic Properties and Factors of Enhancing the Effect

Øgaard¹

2001

Caries Res

111

View full text Add to dashboard Cite

CaF₂ or a CaF₂-like material/phosphate-contaminated CaF₂ is a major reaction product during topical treatment of dental hard tissues. Recently, evidence has suggested that CaF₂ is formed not only on surfaces but also to some extent in the enamel. The minimum concentration of fluoride required for CaF₂ formation is not well known and may depend on whether calcium is available from plaque fluid or only through dissolution of the dental hard tissue. Furthermore, surface adsorption of fluoride to crystals may cause local concentrations necessary for CaF₂ formation. It has been suggested that CaF₂ acts as a pH-controlled reservoir of fluoride. The rate-controlling factor appears to be phosphate, which controls the dissolution rate of CaF₂ at high pH. Increasing fluoride concentration, prolonging the exposure time or using a fluoride solution with low pH can increase CaF₂ formation. CaF₂ formed at low pH contains less internal phosphate which has been shown to be less soluble. This may be of clinical significance for fluoride applied topically a few times per year.

show abstract

“…We speculated that tannin might have interacted with phosphorus and form a tannin-phosphorus complex (38). A previous study demonstrated formation of phosphate-containing CaF 2 on enamel treated with acidified solution with high concentration fluoride (10). The globular precipitate was called CaF 2 -like material because it was contaminated with phosphate and its morphology was different from pure CaF 2 .…”

Section: Discussionmentioning

confidence: 99%

“…High-concentrated fluoride agents have been shown to decrease enamel erosion in vitro and in situ (7)(8)(9). The antierosive effect of fluoride is primarily attributed to the formation of calcium fluoride (CaF 2 )-like material on the dental surfaces (2,10). While fluoride has long been known to have anticariogenic effects, its antierosive potential has remained controversial.…”

Section: Introductionmentioning

confidence: 99%

Effects of tannin-fluoride and milk-fluoride mixture on human enamel erosion from inappropriately chlorinated pool water

2017

View full text Add to dashboard Cite

This in vitro study aimed to investigate the efficacy of tannin-fluoride and milk-fluoride mixtures on human enamel erosion after exposure to inappropriately chlorinated pool water. Enamel specimens were immersed in swimming pool water (pH 2.7) for 30 min and in each test reagent for 4 min once a day for 60 consecutive days (group I: control, group II: tannin-fluoride, group III: milk-fluoride, group IV: tannin-fluoride before and milk-fluoride after erosive challenge, and group V: milk containing tanninfluoride before and after erosive exposure). Surface microhardness was assessed on days 0, 30, and 60. Scanning electron microscopy (SEM) and electron probe microanalysis (EPMA) were performed after treatment of samples for 60 days. Surface microhardness of experimental groups was ranked as follows: group III > group IV-group V > group II > group I (P < 0.05). Moreover, SEM images revealed deposition of substances on erosive enamel surface after treatment with tannin-fluoride and milk-fluoride mixtures. Furthermore, EPMA profiles showed decrease of phosphorus and increase of fluoride content in groups II and IV. In conclusion, we demonstrated that treatment with fluoridated milk with or without tannin-fluoride has protective effects against enamel erosion caused by low-pH swimming pool water.

show abstract

Kinetics of dissolution and growth of calcium fluoride and effects of phosphate

Cited by 103 publications

References 15 publications

The Effect of Fluoride On Apatite Structure and Growth

The Effect of Fluoride On Apatite Structure and Growth

CaF<sub>2</sub> Formation: Cariostatic Properties and Factors of Enhancing the Effect

Effects of tannin-fluoride and milk-fluoride mixture on human enamel erosion from inappropriately chlorinated pool water

Contact Info

Product

Resources

About