Kinetics of gold nanoparticles in the human placenta

Myllynen, Päivi; Loughran, M.; Howard, C. Vyvyan; Sormunen, Raija; Walsh, Adrian A; Vähäkangas, Kirsi

doi:10.1016/j.reprotox.2008.06.008

Cited by 161 publications

(114 citation statements)

References 25 publications

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“…However the penetration pathways are still hypothetical and experimentally unproven. The different results of Myllynen et al (2008) and Wick et al (2010), who used NP of similar sizes, might be attributed to the different surface coatings of the NP. The variation in experimental conditions and NP stability may also contribute to these differences.…”

Section: Ex Vivo Studies In Transplacental Passagementioning

confidence: 95%

“…The NP clusterization might impede their passage through a placental barrier due to an increase in the particle size. A reduced NP transplacental penetration was observed after coating QD with PEG in vivo (Chu et al 2010), and the transfer was totally prevented for PEG coated gold NP in vitro (Myllynen et al 2008).…”

Section: The Possible Mechanisms Of Transplacental Transport Of Npmentioning

confidence: 96%

“…of nanoparticles Myllynen et al (2008) investigated penetration of gold nanoparticles through the placenta barrier using an ex vivo human placenta perfusion model. Monodispersed NP of the size of 10, 15 and 30 nm were coated with PEG and perfused for 6 hours.…”

Section: Ex Vivo Studies In Transplacental Passagementioning

confidence: 99%

“…Therefore, the barrier permeability is possibly increased at the term when compared to the earlier embryogenesis stages. It should be noted that NP accumulation in the trophoblast (Myllynen et al 2008;Menjoge et al 2011) might induce long-term physiological effects on the cellular activity and result in slow NP release to the fetal compartment. These questions were out of the scope in current studies and they are difficult to elucidate using ex vivo techniques.…”

Section: Ex Vivo Studies In Transplacental Passagementioning

confidence: 99%

“…Interestingly, only one study showed NP sequestration in the placental tissue without passing into the fetus: PEG coated 10-30 nm gold nanoparticles (Myllynen et al 2008). Since the NP were modified with a polymer, the size might have increased and the final diameter of the modified NP was undetermined.…”

Section: The Possible Mechanisms Of Transplacental Transport Of Npmentioning

confidence: 99%

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Transport of Nanoparticles through the Placental Barrier

Kulvietis

Žalgevičienė

Didžiapetrienė

et al. 2011

Tohoku J. Exp. Med.

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Nanoparticles (NP) are organic or inorganic substances, the size of which ranges from 1 to 100 nm, and they possess specific properties which are different from those of the bulk materials in the macroscopic scale. In a recent decade, NP were widely applied in biomedicine as potential probes for imaging, drug-delivery systems and regenerative medicine. However, rapid development of nanotechnologies and their applications in clinical research have raised concerns about the adverse effects of NP on human health and environment. In the present review, special attention is paid to the fetal exposure to NP during the period of pregnancy. The ability to control the beneficial effects of NP and to avoid toxicity during treatment requires comprehensive knowledge about the distribution of NP in maternal body and possible penetration through the maternal-fetal barrier that might impair the embryogenesis. The initial in vivo and ex vivo studies imply that NP are able to cross the placental barrier, but the passage to the fetus depends on the size and the surface coating of NP as well as on the experimental model. The toxicity assays indicate that NP might induce adverse physiological effects and impede embryogenesis. The molecular transport mechanisms which are responsible for the transport of nanomaterials across the placental barrier are still poorly understood, and there is a high need for further studies in order to resolve the NP distribution patterns in the organism and to control the beneficial effects of NP applications during pregnancy without impeding the embryogenesis.

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Section: Ex Vivo Studies In Transplacental Passagementioning

confidence: 95%

Section: The Possible Mechanisms Of Transplacental Transport Of Npmentioning

confidence: 96%

Section: Ex Vivo Studies In Transplacental Passagementioning

confidence: 99%

Section: Ex Vivo Studies In Transplacental Passagementioning

confidence: 99%

Section: The Possible Mechanisms Of Transplacental Transport Of Npmentioning

confidence: 99%

See 3 more Smart Citations

Transport of Nanoparticles through the Placental Barrier

Kulvietis

Žalgevičienė

Didžiapetrienė

et al. 2011

Tohoku J. Exp. Med.

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Inductively Coupled Plasma‐Mass Spectrometry in Biodistribution Studies of (Engineered) Nanoparticles

Krystek

Braakhuis

Park

et al. 2013

Encyclopedia of Analytical Chemistry

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The biodistribution of engineered inorganic nanomaterials with size characteristics of one, two, or three dimensions smaller than 100 nm is a fast‐growing analytical and toxicological research field. This review gives a detailed overview about biodistribution studies with gold (Au), silver (Ag), and titanium dioxide (TiO 2 ) nanoparticles (NPs). Exposure to NPs is possible via inhalation, injection, ingestion, and skin contact. The distribution of NPs in the body is affected by their chemical/elemental composition, size and size distribution, shape, coatings, surface properties, and their stability under the selected circumstances. The evaluation of the presence of NPs to determine their tissue distribution is not easy. NP presence can be identified by electron microscopy (EM) but this is a time‐ and labor‐consuming technique. So, instead of determining the presence of the NPs themselves, distribution studies can use elemental analysis by inductively coupled plasma mass spectrometry (ICPMS) as indication for the tissue distribution of NPs. In the field of analytical research, the suitable application of ICPMS is crucial and discussed in detail. Other relevant analytical techniques, the obtained results as well as the evaluations, are presented too.

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Inductively Coupled Plasma‐Mass Spectrometry in Biodistribution Studies of (Engineered) Nanoparticles

Krystek¹,

Cirtiu²,

Braakhuis³

et al. 2019

Encyclopedia of Analytical Chemistry

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The biodistribution of engineered inorganic nanomaterials with size characteristics of one, two, or three dimensions smaller than 100 nm is a fast‐growing analytical and toxicological research field. This article gives a detailed overview of biodistribution studies with gold (Au), silver (Ag), and titanium dioxide (TiO 2 ) nanoparticles (NPs). Exposure to NPs is possible via inhalation, injection, ingestion, and skin contact. The distribution of NPs in the body is affected by their chemical/elemental composition, size and size distribution, shape, coatings, surface properties, and their stability under the selected circumstances. The evaluation of the presence of NPs to determine their tissue distribution is not easy. The presence of NP can be identified by electron microscopy (EM), but this is a time‐ and labor‐consuming technique. So, instead of determining the presence of the NPs themselves, distribution studies can use elemental analysis by inductively coupled plasma‐mass spectrometry (ICP‐MS) as indication for the tissue distribution of NPs. In the field of analytical research, the suitable application of ICP‐MS is crucial and discussed in detail. More recent relevant analytical techniques, especially single‐particle inductively coupled plasma‐mass spectrometry (sp‐ICP‐MS) and the hyphenation of field‐flow fractionation (FFF) hyphenated to ICP‐MS, the obtained results, as well as the evaluations are presented too.

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Kinetics of gold nanoparticles in the human placenta

Cited by 161 publications

References 25 publications

Transport of Nanoparticles through the Placental Barrier

Transport of Nanoparticles through the Placental Barrier

Inductively Coupled Plasma‐Mass Spectrometry in Biodistribution Studies of (Engineered) Nanoparticles

Inductively Coupled Plasma‐Mass Spectrometry in Biodistribution Studies of (Engineered) Nanoparticles

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