Kinetics of HbA1c, Glycated Albumin, and Fructosamine and Analysis of Their Weight Functions Against Preceding Plasma Glucose Level

Tahara, Yasuhiro; Shima, Kenji

doi:10.2337/diacare.18.4.440

Cited by 335 publications

(255 citation statements)

References 15 publications

Supporting

Mentioning

238

Contrasting

Unclassified

Order By: Relevance

“…In other words, glucose levels during the most recent 6 week period will have a greater influence on the A1c result compared to levels from the prior 6 weeks. 8 Thus, if the patient has experienced a recent acute change in glycemic control (i.e., treatment with glucocorticoids), the A1c value will be disproportionately affected by the most recent glucose levels. Table 1 shows the correlation between A1c and estimated average glucose.…”

Section: Description Of Hemoglobin A1cmentioning

confidence: 99%

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

2013

View full text Add to dashboard Cite

Section: Description Of Hemoglobin A1cmentioning

confidence: 99%

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

2013

View full text Add to dashboard Cite

“…It is measured with the automatic clinical chemistry analyzer currently used in the blood centers without any change in the testing process. Furthermore, GA is not affected by the contents of meals taken on the day of the measurement 5 , which suits the blood donation environment, because blood donors are encouraged to take some refreshment before or after donation to mitigate or prevent vasovagal reactions characterized by sudden decreases in blood pressure and heart rate.…”

Section: Introductionmentioning

confidence: 99%

Introduction of glycated albumin measurement for all blood donors and the prevalence of a high glycated albumin level in Japan

Araki

Ishikawa

Okazaki

et al. 2012

J of Diabetes Invest

View full text Add to dashboard Cite

(J Diabetes Invest, doi: 10.1111/j.2040‐1124.2012.00224.x, 2012) Aims/Introduction: The Japanese Red Cross Society introduced measurement of glycated albumin (GA) for all blood donors as a glycemic control marker. The GA levels were examined by sex and age.Materials and Methods: GA was measured in 3.14 million blood donors who donated between April 2009 and March 2010. For the reference range for GA, values that were three times the reference range for glycated hemoglobin (Japan Diabetes Society value) were used. All donors were notified of their GA levels. For repeat donors, a comparison was made between the GA levels at the first and second donations to verify the GA change after notification.Results: The mean GA was significantly lower in males than in females in donors aged <60 years. The mean GAs of both sexes increased with age and reached the same level of 14.8% in their 60s. The percentage of donors with prediabetes/diabetes (GA ≥16.5%) was 2.8% in males and 2.3% in females. In the normal high group (15.6% ≤ GA < 16.5%), the mean GA at the second donation was lower by 0.20% than at the first donation. In 42.4% of these donors, GA decreased to the normal range at the second donation.Conclusions: Overall, 2.7% of otherwise healthy Japanese blood donors had a high GA (GA ≥16.5%). Donor blood screening for GA represents an effective measure to identify people at risk of diabetes. The decrease in the GA level after GA notification might indicate the potential usefulness of this strategy to improve glycemic control among people with high GA.

show abstract

“…Measurement of GA has been commonly advocated in human patients with diabetes and can also provide an index of glycemic control for 1-3 weeks. 3,9,10 The working hypothesis of the current study was that GA could be substituted for fructosamine in the diagnosis and treatment monitoring of diabetic dogs because GA is a main constituent of fructosamine.…”

mentioning

confidence: 99%

Diagnostic Significance of Serum Glycated Albumin in Diabetic Dogs

et al. 2008

View full text Add to dashboard Cite

Abstract. Measurements of serum fructosamine, glycated hemoglobin, and glycated albumin (GA) are increasingly used to complement serum glucose concentration for better management of diabetes mellitus. Fructosamine tests are currently not performed in veterinary medicine in Japan. As such, the measurement of GA may serve as a replacement test. Therefore, in the current study, serum GA and fructosamine were evaluated for a positive correlation in dogs, and, depending on the correlation, a reference range of GA percentage would also be determined from healthy control dogs. The degree of glycemic control in diabetic dogs was determined by fructosamine concentration. A positive correlation between GA and fructosamine was observed with both normal and diabetic animals. In addition, the reference interval of serum GA percentage in control dogs was determined to be 11.4-11.9% (95% confidence interval). Interestingly, no significant difference in serum GA percentages was observed between samples from diabetic dogs with excellent glycemic control and control dogs. However, good, fair, and poor glycemic control diabetic dogs resulted in a significant increase in serum GA percentages in comparison with control dogs. These results suggest that serum GA may be a useful diagnostic indicator, substituting for fructosamine, to monitor glycemic control in diabetic dogs.

show abstract

Kinetics of HbA1c, Glycated Albumin, and Fructosamine and Analysis of Their Weight Functions Against Preceding Plasma Glucose Level

Abstract: The levels of HbA1c, GA, and FA do not reflect the simple mean but reflect the weighted mean of the preceding plasma glucose level over a considerably longer period than was previously speculated.

Cited by 335 publications

References 15 publications

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

Introduction of glycated albumin measurement for all blood donors and the prevalence of a high glycated albumin level in Japan

Diagnostic Significance of Serum Glycated Albumin in Diabetic Dogs

Contact Info

Product

Resources

About