Kinetics of Homovanillic Acid and determination of its production rate in the rhesus monkey

Elchisak, Mary Ann; Polinsky, Ronald J.; Ebert, M H; Modlin, L.T.; Kopin, Irwin J.

doi:10.1016/0024-3205(79)90033-x

Cited by 16 publications

(10 citation statements)

References 12 publications

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“…*, ",Basal excretion of 4.46 Ug/min of HVA, considered to be a major metabolite of DA in humans, is in the range reported earlier (Elchisok, Polinsky, Ebert, and Kopin, 1982 Rates of excretion of 5HT were significantly decreased in SIM, CHECK, and SPIN tests, but were unchanged in the INSTR ride. Basal rate of the major 511T metabolite 5-HIAA at 3.74 (+ 0.41) ug/min was similar to that earlier reported for human controls; i.e., 3.4 (+ 0.76) Ug/min (Himwich, 1970).…”

Section: S'ssupporting

confidence: 60%

Biochemical Measurements of the Human Stress Response

Krahenbuhl¹,

Harris²

1984

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Section: S'ssupporting

confidence: 60%

Biochemical Measurements of the Human Stress Response

Krahenbuhl¹,

Harris²

1984

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“…In contrast to plasma HVA it is unclear whether CSF HVA can reflect cortical dopaminergic neural activity, since HVA from most regions of the brain seems to enter directly into blood circulation without ever appearing in CSF (Neff et al, 1967;Meek and Neff, 1973;Aizenstein and Korf, 1978). The mean half-life of plasma HVA in humans appears to be 1 h (Anggard et al, 1974;Elchisak et al, 1982). It is mainly renally excreted (Elchisak et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

“…The mean half-life of plasma HVA in humans appears to be 1 h (Anggard et al, 1974;Elchisak et al, 1982). It is mainly renally excreted (Elchisak et al, 1979). The effect of diet on plasma HVA lasts several hours, but overnight fasting eliminates the dietary effects on plasma HVA concentrations in humans (Davidson et al, 1987;Elsworth et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene

Köhnke¹,

Wiatr²,

Kolb³

et al. 2002

Neuropsychopharmacol

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The central dopamine system seems to influence addictive disorders. Plasma homovanillic acid (HVA) is an indicator of central dopaminergic activity. In this study the hypothesis that plasma HVA is associated with alcoholism or with delirium tremens (DT) during alcohol withdrawal was tested. A functional genetic polymorphism of the enzyme catechol-O-methyltransferase (COMT) that participates in converting dopamine into its final metabolite HVA was investigated for an association with alcoholism or DT during alcohol withdrawal. In addition, a relation between the functional polymorphism of COMT and plasma HVA concentrations was studied. Plasma HVA concentrations and COMT genotypes were determined in 142 German alcoholics and 101 German healthy controls. Alcoholic patients were examined after a minimum of 3 weeks after cessation of drinking. Mean plasma HVA concentrations were significantly lower in alcoholic patients compared to healthy controls. A group of alcoholics with a history of DT during alcohol withdrawal (n ¼ 62) did not differ significantly in plasma HVA concentrations from alcoholics with a history of only mild withdrawal symptoms (n ¼ 67). The functional polymorphism of the human COMT gene was neither significantly associated with the diagnosis of alcoholism or DT during alcohol withdrawal nor with plasma HVA concentrations.

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“…Plasma turnover of DHPG is faster than that of HVA (Eisenhofer et al, 1989;Elchisak et al, 1982) and therefore decrease in MAO inhibition (increase in DHPG) is reflected more rapidly in plasma DHPG than in plasma HVA concentration. Therefore plasma DHPG may be a more rapid and perhaps more sensitive indicator of MAO-A inhibition than plasma HVA concentration.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase‐A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects.

Berlin

Zimmer

et al. 1990

Brit J Clinical Pharma

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1 The effects of two reversible, predominantly monoamine oxidase-A (MAO-A) inhibitors, moclobemide (150 mg three times daily) and toloxatone (400-200-400 mg day-1) on monoamine metabolites and psychometric performance were compared in a double-blind placebo controlled crossover study in 12 healthy subjects. 2 After 7 days of moclobemide/toloxatone/placebo administration subjects were hospitalized for 24 h on day 8. Blood samples were drawn every 2 h for determination of plasma noradrenaline (NA), 3,4-dihydroxyphenylglycol (DHPG), homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA). Urine was collected for measurements of normetanephrine and 3-methoxytyramine excretion. Psychometric performance (short-and long-term memory, critical flicker fusion frequency, choice reaction time) and subjective feelings were assessed before each drug intake (in the morning, at noon, in the evening). 3 Compared with placebo, both reversible monoamine oxidase inhibitors decreased the plasma concentration of DHPG and HVA. The overall fall in DHPG (AUC from 0 to 24 h) was 44% during moclobemide and 12% during toloxatone (P < 0.001) and the overall decrease in HVA was 38% and 20% (P < 0.005) on moclobemide and toloxatone, respectively. 4 Before the next drug intake, MAO-A inhibition, as judged by the decrease of plasma DHPG concentration, was significantly different from placebo with moclobemide but not with toloxatone. 5 Moclobemide, but not toloxatone, exerted a moderate, but significant inhibition of the deamination of 5-hydroxytryptamine (5-HT) as judged by the fall in plasma 5-HIAA concentration. Neither drug influenced plasma NA concentration. 6 A significant rise in urinary excretion of normetanephrine was observed on moclobemide and to a lesser extent on toloxatone. The urinary excretion of 3-methoxytyramine was significantly raised by moclobemide but not by toloxatone. 7 Neither moclobemide nor toloxatone altered memory function, vigilance, subjective feelings or sleep characteristics of the subjects.

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Kinetics of Homovanillic Acid and determination of its production rate in the rhesus monkey

Cited by 16 publications

References 12 publications

Biochemical Measurements of the Human Stress Response

Biochemical Measurements of the Human Stress Response

Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene

Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase‐A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects.

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