Kinetics of ion exchange. VII. Measurements in the film diffusion region

NMR Analysis of Pharmaceuticals XII: Determination of Amantadine Hydrochloride in Soft Gelatin Capsules and Syrups

“…Other procedures are direct and are based on reaction with coulometrically generated bromine (2) in a buffered medium, titrimetry (3) in which I is determined by residual base titration of a distillate collected in 0.1 N HC1, and potentiometric titration (4) of I in a nonaqueous medium with perchloric acid. Indirect procedures carried out after derivative formation (1) include a GLC determination, which is based on the conversion of I into 1-(chloroa-cetamid0)adamantate by reaction with chloroacetic anhydride, and a spectrophotometric method, which consists of measuring the UV absorption of 1-(p-ni-trobenzy1idineamino)adamantane obtained by the reaction of I with p-nitrobenzaldehyde.…”

“…Keyphrases Polymers, silicone rubber matrix-determination of dispersed progesterone and cholesterol, differential scanning calorimetry Progesterone-determination of concentration dispersed in silicone rubber matrix, four dispersed polymorphic forms observed, heat of mixing and solubility at drug melting point determined, differential scanning calorimetry Cholesterol-determination of concentration dispersed in silicone rubber matrix, differential scanning calorimetry Silicone rubber-determination of dispersed progesterone and cholesterol, differential scanning calorimetry Polydimethylsiloxane-determination of dispersed progesterone and cholesterol, differential scanning calorimetry Differential scanning calorimetry-analysis, progesterone and cholesterol dispersed in silicone rubber matrix Differential scanning calorimetry has been employed for semiempirical determinations of purities of drug substances (1,2) and for kinetic studies of polymorphic phase transitions (3). In the present study, the technique was used to determine quantitatively the concentration of solid drugs dispersed in a polymeric matrix.…”