2021
DOI: 10.3389/fimmu.2021.674079
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Kinetics of Neutrophil Subsets in Acute, Subacute, and Chronic Inflammation

Abstract: At homeostasis the vast majority of neutrophils in the circulation expresses CD16 and CD62L within a narrow expression range, but this quickly changes in disease. Little is known regarding the changes in kinetics of neutrophils phenotypes in inflammatory conditions. During acute inflammation more heterogeneity was found, characterized by an increase in CD16dim banded neutrophils. These cells were probably released from the bone marrow (left shift). Acute inflammation induced by human experimental endotoxemia (… Show more

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Cited by 41 publications
(41 citation statements)
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“…These cells have higher antibacterial activity than CD16 high CD62L high neutrophils, are hypersegmented and suppress T cell proliferation. CD16 low and CD62L low neutrophils increase during acute inflammatory conditions in patients with trauma or infection or after LPS challenge, while chronic inflammation (COPD and HIV) does not affect circulating levels of CD16 low and CD62L low neutrophils [ 68 ]. The difficulty in defining neutrophil heterogeneity by gradient density and/or surface markers has led to the use of single-cell sequencing to characterize and define different neutrophil subpopulations in steady-state conditions and during disease.…”
Section: Neutrophil Heterogeneity In Chronic Inflammationmentioning
confidence: 99%
“…These cells have higher antibacterial activity than CD16 high CD62L high neutrophils, are hypersegmented and suppress T cell proliferation. CD16 low and CD62L low neutrophils increase during acute inflammatory conditions in patients with trauma or infection or after LPS challenge, while chronic inflammation (COPD and HIV) does not affect circulating levels of CD16 low and CD62L low neutrophils [ 68 ]. The difficulty in defining neutrophil heterogeneity by gradient density and/or surface markers has led to the use of single-cell sequencing to characterize and define different neutrophil subpopulations in steady-state conditions and during disease.…”
Section: Neutrophil Heterogeneity In Chronic Inflammationmentioning
confidence: 99%
“…Baseline neutrophil CD62L expression was still decreased and similar to expression during active disease. Circulatory CD62L dim /CD16 bright "hypersegmented" neutrophils have been described in the context of trauma, experimental endotoxemia and exercise (32)(33)(34). "Hypersegmented" neutrophils are thought to be a truly separate subset that has poor bacterial killing capacities and inhibits T-cell proliferation (35)(36)(37).…”
Section: Aberrant Granulocyte Responses Months After Active Covid-19 ...mentioning
confidence: 99%
“…It is still unclear for many subsets if they are bona fide lineages or simply differentiations and/or maturation states induced by the tissue environment(s). Certainly upon chronic inflammation there can be substantial increases in novel marker expression, which has been long known in respiratory diseases [17], as well as shifts in the maturity of systemic neutrophil populations during severe inflammatory trauma resulting in CD16 low and CD62 low populations [18]. Neutrophils have also been observed as rare events in mononuclear separations of blood and these cells, termed low density neutrophils, have been implicated in a variety of diseases [12].…”
Section: Neutrophil Developmentmentioning
confidence: 99%