Kinetics of oxidation of chloroprocaine hydrochloride by N-halo-p-toluene sulfonamides in acid medium: A Mechanistic approach

Shubha, J.P.; Manjunath, R.; wamy, Puttas

doi:10.9790/5736-075396103

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…With levamisole S-oxide as the oxidation product and TsNHBr + as the active oxidising species, a reaction stoichiometry of 1:1 was recorded. 105 The reaction rate exhibits first-order kinetics in terms of both [oxidant] 0 and [substrate] 0 , and fractional-order kinetics in terms of the acid concentration, thereby leading to the rate law: rate = k[CAB] 0 [substrate][H + ] 0.47 . The reaction rate increases with a fall in the dielectric constant of the medium, but a change in the ionic strength of the medium or the addition of p-toluenesulfonamide did not have any impact on the reaction kinetics.…”

Section: Scheme 73 Oxidation Of Piperazines By Bromamine-tmentioning

confidence: 99%

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

Kashyap¹,

Phukan²

2023

Synlett

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Bromamine-T (BAT) is a distinguished member of a special class of compounds called organic haloamines, possessing oxidising properties. It can act as the source of halonium ions, hypohalite species, and N-anions, along with the display of basic as well as nucleophilic properties. Bromamine-T finds wide application as an efficient reagent for various organic transformations such as aminobromination, amination, oxidation etc., under mild conditions with minimum toxicity. Moreover, due to its immense biological significance, this reagent is piquing the interest of numerous researchers.

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Section: Scheme 73 Oxidation Of Piperazines By Bromamine-tmentioning

confidence: 99%

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

Kashyap¹,

Phukan²

2023

Synlett

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“…The reaction has been studied at various temperatures, and activation parameters were established. Measure of elements of the reaction was found to be 1:1 and the degradation product formed by oxidation was identified by using spectral analysis (Shubha and Sushma 2015).…”

Section: Systematic Strategies To Perform Degradation Kineticsmentioning

confidence: 99%

Systematic strategies for degradation kinetic study of pharmaceuticals: an issue of utmost importance concerning current stability analysis practices

et al. 2022

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Degradation kinetic study ascertains the shelf life of drugs under different environmental conditions. It can facilitate the prediction of specific critical factors that can affect the quality of pharmaceuticals during storage. To date, general systematic strategies for performing degradation kinetics of drugs have not been discussed in any literature. Moreover, no regulatory guideline is available on the degradation kinetic study of pharmaceuticals. Owing to this, the kinetic behavior of drugs is not being analyzed uniformly. This article provides a detailed insight into degradation kinetic approaches including criticality in selecting different variables for the study. Factors that can affect the quality of degradation kinetic study data have been critically discussed. In addition, a systematic strategy to perform degradation kinetic study with advanced degradation models has been discussed. This article will be helpful for the researcher working in the field of stability analysis and guide to select a logical path for determining the kinetic behavior of drugs. High-quality degradation kinetic data through the properly designed study will help to establish accurate storage conditions of pharmaceuticals. This article is unique and novel of its kind and would have a significant contribution to the field of stability analysis.

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Donepezil oxidation: complementary chemical and spectroscopic exploration of products, mechanism and kinetics

Malini¹,

Raj²,

Suresha

et al. 2021

Chem. Pap.

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Kinetics of oxidation of chloroprocaine hydrochloride by N-halo-p-toluene sulfonamides in acid medium: A Mechanistic approach

Abstract: Abstract:A kinetic study of oxidation of a potent local anaesthetic chloroprocaine hydrochloride by sodium Nhalo-p-toluenesulfonamides (chloramine-T and bromamine-T)

Cited by 3 publications

References 19 publications

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

Systematic strategies for degradation kinetic study of pharmaceuticals: an issue of utmost importance concerning current stability analysis practices

Donepezil oxidation: complementary chemical and spectroscopic exploration of products, mechanism and kinetics

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