Kinetics of Pancreatic Exocrine Secretion and Plasma Gut Regulatory Peptide Release in Response to Feeding in Preruminant and Ruminant Calves

Development of gastrointestinal and pancreatic functions in mammalians (mainly bovine and porcine species): influence of age and ingested food

“…Thus, G cells, which produce gastrin, may be more responsive to solid than liquid feed [55]. Higher concentrations of PP possibly reflect a prolonged stimulation of the parasympathetic system [7] [26,71,98,118], in agreement with the pattern of pancreatic secretion which is not affected by feeding [71,101,151]. The …”

“…However, in preruminant calves and in pigs, pre-feeding and/or postfeeding plasma levels of many peptides were highly affected [14,40] [66] and for CCK [18], as well as for the amounts of protein (a amino nitrogen) absorbed for gastrin, glucagon, insulin and PP [107]. Moreover, a modification of the vagally dependent cephalic phase of pancreatic secretion with a soybean diet is noteworthy and is described in preruminant calves [71,102]. The higher pancreatic prandial protein and especially trypsin concentrations and trypsin outflows with a soybean diet as compared with a milk diet could be related to the higher basal levels of CCK and gastrin which have been shown to stimulate pancreatic juice outflow in preruminant calves [69,146].…”

“…data, [151]). However, it is important to mention that these changes also involve the kinetics of preprandial and postprandial pancreatic secretion in milk-fed calves, which is different in the morning and evening [71,151]. In experiments with conscious or anaesthetized pigs, no age effect is observed between 1-2 and [4][5] weeks; daily basal secretion of pancreatic juice is about 5-14 mL.kg-I BW [49,101].…”

“…Thus, at 4 months of age, tissular chymotrypsin, carboxypeptidase A, amylase and lipase activities are 1.6-to 4-fold higher in weaned calves than in milk-fed calves. The daily pancreatic secretion, as well as the prefeeding and postfeeding secretions, of fluid, protein and trypsin are also increased by 20-240 % in weaned calves [71]. Larger digestive contents, more regular flow of digesta into the duodenum with lower pH, and different end products may be responsible for the enhancement of enzyme expression.…”

Collection of pancreatic juice in experimental animals: mini-review of materials and methods

“…By means of these tools, several important data have been obtained conceming the kinetics of daily pancreatic secretion (circadian and ultradian rhythms, effects of meal), and the influence of regulatory peptides given in small, physiological-like doses (Itoh et al, 1980;Naruse et al, 1992, Kiela et al, 1996. (Itoh et al, 1980;Juste et al, 1983;Le Dr6an et al, 1997 (Wensing and Counotte, 1995).…”