Kinetics of peroxidase-catalyzed oxidation of quercetin in the presence of β-cyclodextrin

Oleinik, L. I.; Buslova, T. S.; Veselova, I. A.; Шеховцова, Т. Н.

doi:10.3103/s0027131411030084

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Выявленное Олейник с соавт. [40] незначительное (на 20 %) возрастание скорости пероксидазного окисления кверцетина в присутствии β-CD авторы объясняют неспецифическим взаимодействием β-CD с продуктами окисления флавоноидов.…”

Section: результаты протекторный эффект кверцетина и комплекса кверцunclassified

Quantum-chemical modeling of the electronic structure of quercetin and inhibition by quercetin and quercetin–hydroxypropyl-β-cyclodextrin complex of lipid peroxidation in mitochondria and red blood cells of rats

Veiko

Ilyich

Лапшина

et al. 2018

Vescì Akademìì navuk Belarusì. Seryâ biâlagičnyh navuk

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Quercetin (3,3ʹ,4ʹ,5,7-pentahydroxyflavon), one of the most common and studied flavonoids, possesses the antioxidant activity and demonstrates the pronounced therapeutic potential under a number of pathological conditions. The purpose of this work is to estimate the electronic structure of the quercetin and its semi-quinone radical molecules and to compare the antioxidant activities of quercetin and its inclusion complex with hydroxypropyl-β-cyclodextrin. Generation of maps of the electron density distribution in quercetin and quercetin semi-quinone radical molecules showed that the active electron orbitals (HOMO and LUMO) are delocalized over all phenolic rings providing the radical stabilization. We have showed that quercetin prevents the tert-butyl hydroperoxide-induced lipid peroxidation of erythrocytes (IC50 = 25 ± 3 μM) and mitochondrial membranes (IC50 = 31 ± 4 μM). The efficiency of quercetin inhibition the reduced glutathione oxidation in erythrocytes and mitochondria is much lower reflecting the lipophilicity of polyphenol. Quercetin also prevented the hypochlorite-induced lysis of red blood cells (IC50 = 3 ± 0.5 μM). Our data revealed that the quercetin-hydroxypropyl-β-cyclodex-trin complex is more effective inhibitor of the membrane lipids peroxidation and glutathione oxidation processes.

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Section: результаты протекторный эффект кверцетина и комплекса кверцunclassified

Quantum-chemical modeling of the electronic structure of quercetin and inhibition by quercetin and quercetin–hydroxypropyl-β-cyclodextrin complex of lipid peroxidation in mitochondria and red blood cells of rats

Veiko

Ilyich

Лапшина

et al. 2018

Vescì Akademìì navuk Belarusì. Seryâ biâlagičnyh navuk

View full text Add to dashboard Cite

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Quercetin and its Complex with Cyclodextrin against Oxidative Damage of Mitochondria and Erythrocytes: Experimental Results in vitro and Quantum-Chemical Calculations

et al. 2018

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Kinetics of peroxidase-catalyzed oxidation of quercetin in the presence of β-cyclodextrin

Cited by 2 publications

References 9 publications

Quantum-chemical modeling of the electronic structure of quercetin and inhibition by quercetin and quercetin–hydroxypropyl-β-cyclodextrin complex of lipid peroxidation in mitochondria and red blood cells of rats

Quantum-chemical modeling of the electronic structure of quercetin and inhibition by quercetin and quercetin–hydroxypropyl-β-cyclodextrin complex of lipid peroxidation in mitochondria and red blood cells of rats

Quercetin and its Complex with Cyclodextrin against Oxidative Damage of Mitochondria and Erythrocytes: Experimental Results in vitro and Quantum-Chemical Calculations

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