Kinetics of proliferation, cell differentiation, and IgM secretion in the omental lymphoid organ of B10/Sn mice following intraperitoneal immunization with sheep erythrocytes

Dux, Kazimierz; Janík, P.; Szaniawska, B

doi:10.1016/0008-8749(77)90185-x

Cited by 21 publications

(5 citation statements)

References 7 publications

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“…Previous work suggested that the omentum had an immunological function and showed that plasma cells could be found in the omentum after intraperitoneal immunization with T-independent antigens (Ansel et al, 2002; Ha et al, 2006) as well as classic T-dependent antigens (Dux et al, 1977; Hajdu et al, 1972; Van Vugt et al, 1996). Nevertheless, some authors have concluded that the MS should not be classified as secondary lymphoid organs (Szaniawska, 1974; Szaniawska, 1975; Van Vugt et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

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Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

et al. 2009

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Summary The omentum is a site of B1 lymphopoiesis and immune responsiveness to T-independent antigens. However, it is unknown whether it supports immune responses independently of conventional lymphoid organs. We show that the omentum collects antigens and cells from the peritoneal cavity and supports T-dependent B cell responses, including isotype switching, somatic hypermutation and limited affinity maturation, despite the lack of identifiable follicular dendritic cells. The omentum also supports CD4 and CD8 responses to peritoneal antigens and recruits effector T cells primed in other locations. Unlike conventional lymphoid organs, milky spots in the omentum develop in the absence of lymphoid tissue inducer cells, but require CXCL13. Although the lymphoid architecture of milky spots is disrupted in lymphotoxin-deficient mice, normal architecture is restored by reconstitution with lymphotoxin-sufficient hematopoietic cells. These results indicate that the milky spots of the omentum function as unique secondary lymphoid organs that promote immunity to peritoneal antigens.

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Section: Discussionmentioning

confidence: 99%

“…Plasma cell responses to some T-dependent antigens are observed in the omenta of mice immunized i.p. (Dux et al, 1977; Dux et al, 1986; Hajdu et al, 1972) and the surgical removal of the omentum in rabbits reduces the antibody response to i.p. SRBC by 75% (Portis, 1924), suggesting that the MS may be secondary lymphoid organs.…”

Section: Introductionmentioning

confidence: 99%

Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

et al. 2009

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“…12 The basic findings in this study are, first, that INDO which contains in the mouse a specialized lymphoid tissue, can inhibit plasmacytomagenesis initiated by the highly efthe milky spots, or omental lymphoid organ. [21][22][23][24] During i.p. fective three-dose schedule of pristane administration.…”

Section: Inhibition Of Plastic Disc Induced Pct Formation By Indomentioning

confidence: 99%

Indomethacin Is a Potent Inhibitor of Pristane and Plastic Disc Induced Plasmacytomagenesis in a Hypersusceptible BALB/c Congenic Strain

Potter

Wax

Jones

1997

Blood

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Continuous indomethacin (INDO) administration in the drinking water (10 to 20 μg/mL) profoundly inhibited plasmacytoma (PCT) development initiated by three 0.2- or 0.5-mL intraperitoneal (i.p.) injections of pristane in hypersusceptible BALB/c.DBA/2-Idh1-Pep3 congenic mice. The most effective inhibitions were obtained with continuous INDO treatment. When treatment was delayed until 50 to 60 days after the first pristane injection, there was approximately a 50% reduction in PCT incidence. The primary action of pristane is the induction of a chronic inflammation in the peritoneal connective tissues and the formation of a microenvironment where PCTs develop. INDO, a powerful inhibitor of prostaglandin synthases (cyclooxygenases 1 and 2), did not inhibit the formation of mesenteric oil granuloma nor the appearance of cells in this chronic inflammatory tissue carrying c-myc illegitimately joined to an Ig heavy chain switch region, ie, the t(12; 15) chromosomal translocation. INDO inhibited PCT induction by the i.p. implantation of 21 × 2 mm polycarbonate discs. These solid objects predominantly induce the formation of a patchy fibroplastic tissue on contacting peritoneal surfaces. These and previous data indicate that indomethacin inhibits an intermediate stage in PCT development after the arrival of cells bearing the T(12; 15) translocation in the oil granuloma and before these cells acquire transplantability to a pristane-conditioned host. The biological mechanism that explains how INDO inhibits PCT development is not yet established but appears to result from decreased production of prostaglandins in chronic inflammatory tissues (oil granuloma, fibroplasia), suggesting that prostaglandins play an active role in oil and solid plastic induced PCT formation.

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“…According to the present knowledge, the MS are implicated in several important biological functions. They represent a major immune organ in the peritoneal cavity (5,8,(19)(20)(21)(22)(23)(24)(25)(26). Further, MS produce and provide free peritoneal cells, such as macrophages/monocytes and lymphocytes (11,12,(26)(27)(28)(29)(30)(31).…”

Section: Michailova and Usunoffmentioning

confidence: 99%

The milky spots of the peritoneum and pleura: structure, development and pathology

Michailova

Usunoff

2004

Biomedical Reviews

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The milky spots (MS), originally described by Ranvier as taches laiteuses, are found on the greater omentum but also in other peritoneal regions, as well as on the pleura and pericardium. They represent aggregations of mesenchymal tissue surrounding blood vessels. These small whitish regions are covered by mesothelium, and within the mesothelial layer are scattered macrophage-like cells. The blood supply of MS is provided by arterioles that give rise to capillary network formed by fenestrated or continuous endothelial cells. Most MS possess also lymphatic vessels, with extremely thin endothelial cells. The most frequent cells in MS are the macrophages, followed by lymphocytes and mast cells. Typically, the macrophages are located in the periphery, while the lymphocytes-in the center of MS. Additional structural elements are plasmocytes, adipocytes, fibroblasts, rounded fibroblast-like cells (undifferentiated mesenchymal cells), as well as collagen, reticular and elastic fibers. The nerve fibers innervating MS are located under the mesothelium and among the free cells. Despite their small size, the MS are a significant organ, functioning at both normal and pathological conditions. Under inflammatory conditions (peritonitis), MS act as the first line of defense, and dramatically change their number, size and structure. MS are also involved in extramedullary hemopoiesis. They are the first target of intraperitoneal (intrapleural) metastases, and appear an important target in the development of immunotherapeutic strategies against malignant diseases.

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Kinetics of proliferation, cell differentiation, and IgM secretion in the omental lymphoid organ of B10/Sn mice following intraperitoneal immunization with sheep erythrocytes

Cited by 21 publications

References 7 publications

Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

Indomethacin Is a Potent Inhibitor of Pristane and Plastic Disc Induced Plasmacytomagenesis in a Hypersusceptible BALB/c Congenic Strain

The milky spots of the peritoneum and pleura: structure, development and pathology

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