The progress in the laser technology makes it possible to produce a laser pulse having a peak power of over PW. Focusing such high-power laser pulses enables ones to have unprecedentedly strong laser intensity. The laser intensity over 10 19 W/cm 2 , which is called the relativistic laser intensity, can accelerate electrons almost to the speed of light. The acceleration of charged particles using such a high-power laser pulse has been successfully demonstrated in many experiments. According to the recent calculation using the vector diffraction theory, it is possible, by employing a tight focusing geometry, to produce a femtosecond (fs) laser focal spot to have an intensity of over 10 24 W/cm 2 in the focal plane. Over this laser intensity, protons can be directly accelerated almost to the speed of light. Such ultrashort and ultrastrong laser intensities will bring ones many opportunities to experimentally study ultrafast physical phenomena we have never met before. This chapter describes how to generate a high-power laser pulse. And, then the focusing characteristics of a femtosecond high-power laser pulse are discussed in the scalar and the vector diffraction limits. Finally, the applications of ultrashort high-power laser are briefly introduced.