Kinetics of the Degradation of Isoamyl Nitrite in Ampuls I.**School of Pharmacy, University of Wisconsin, Madison

NMR Stability Assay for Amyl Nitrite Ampuls

“…The decomposition of amyl nitrite does not alter the number of methyl groups present, but it does reduce the number of -CHr O N 0 groups (14)(15)(16)(17)(18). This allows the degradation of the compound to be followed by determining the ratio of the number of -CHZ-ON0 groups to the number of methyl groups.…”

“…N20, NO, CO, COz, and at least 12 liquid components including water, amyl alcohol, isovaleric acid, isovaleraldehyde, amyl isovalerate, and amyl nitrate (14)(15)(16)(17)(18). In this paper, an NMR stability assay which is very rapid and which avoids most of the difficulties associated with previous methods is reported.…”

Prediction of Stability of Drugs and Pharmaceutical Preparations

“…Other examples of the application of these predictive techniques in pharmaceutical formulations are for ascorbic acid in a liquid multivitamin emulsion containing fluoride (1 SO), the kinetics of degradation of amyl nitrite ampuls (196,197), and the stability of ergonovine inaleate (139). Publications of interest in this regard are studies on the influence of the effect of heating and cooling time on prediction of shelf-life by kinetic principles and the Arrhenius equation a t exaggerated temperatures (35).…”