Kinetics of the formylation of thiophene derivatives with N,N-dimethylformamide

β-Formyl-BODIPYs from the Vilsmeier−Haack Reaction

“…The Vilsmeier−Haack reaction of pyrroles using DMF/POCl 3 has been extended to thiophenes, indoles, bipyrroles, porphyrins, chlorins, and dipyrromethanes and represents highly efficient approaches to the introduction of various substituents into specific positions of these molecules. For example, formylporphyrins, in general, and β-formylporphyrins, in particular, are valuable precursors in the synthesis of porphyrin derivatives with important applications in biomedical and natural sciences .…”