Kinetics of the inflammatory response during experimental Babesia rossi infection of beagle dogs

The dataset for the inflammatory response during experimental infection and treatment of dogs with Babesia rossi

“…Differences between this experimental infection and natural infections can be identified, allowing the refinement of future studies. There are several experimental studies on the inflammatory response to different canine Babesia species and our study will provides the groundwork for comparisons between the various species and may highlight possible reasons for the increased virulence of this particular species in the canine population [4] , [5] .…”

“… This time course study of markers of inflammation in experimental Babesia rossi infection will improve our understanding of the evolution of the systemic inflammatory response associated with canine babesiosis [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] . This data will add to the growing database for Babesia research and will assist with our ongoing endeavours to optimise our approach to the treatment of this disease.…”

“…This data will add to the growing database for Babesia research and will assist with our ongoing endeavours to optimise our approach to the treatment of this disease. We will compare this canine disease with other important blood-borne protozoal infections affecting humans and animals, to better grasp the pathophysiology of this group of infections [4] , [5] , [6] , [14] , [15] , [16] , [17] . In addition to this, an established experimental B. rossi infection may potentially provide a disease model for blood-borne protozoal disease and haemolytic disease [14] , [17] , [18] .…”

“… The information gained from this study benefits veterinarians faced with the treatment of this disease, particularly in Sub-Saharan Africa [19] . It may also benefit veterinarians worldwide by improving our understanding of the physiological reaction to this group of infectious agents and the impact treatment has on the progression of disease [4] , [5] , [6] . Using this infection as a model for similar infectious diseases in humans, such as malaria and zoonotic babesiosis, as well as a model for haemolytic disease could provide greater understanding of similar diseases and provide future treatment targets benefiting both human and veterinary health care [14] , [15] , [16] , [17] .…”

Pathogenesis of Anemia in Canine Babesiosis: Possible Contribution of Pro-Inflammatory Cytokines and Chemokines—A Review

“…Pro-inflammatory cytokines and chemokines, particularly tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), monocyte chemoattractant protein 1 (MCP-1, also known as CCL2), keratinocyte-derived chemokine (KC, also known as CXCL1)-like, interferon gamma-induced protein 10 (IP-10, also known as CXCL10), interleukin 6 (IL-6), IL-8 (also known as CXCL8), IL-12, IL-18, granulocyte-macrophage colony-stimulating factor (GM-CSF, also known as CSF-2), and high-mobility group box-1 protein (HMGB-1), play a role in the development of many of these complications. Moreover, insufficient and/or delayed production of anti-inflammatory cytokines, such as IL-4 and IL-10, also contributes to the pathogenesis of both diseases, including hematological changes [ 2 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”