Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes

Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16INK4a gene in human colorectal carcinoma (Caco-2) cells

“…We showed that this betaxanthin behaves as a radical scavenger and antioxidant [12][13][14], interacts with and locates in membranes [15,16], and affects cell redox-sensitive signaling pathways [17,18]. When consuming cactus pear fruits, Ind is stable at the digestive conditions, not metabolized by the enterocytes, and highly bioavailable in humans in its native form [19][20][21].…”

Indicaxanthin Dietetics: Past, Present, and Future

“…The differential pulse voltammogram showed two anodic waves, with calculated peak potentials of 611 and 895 mV indicating that indicaxanthin is able to donate its electrons to organic radicals commonly formed in cell environments, including alkyl-peroxyl and lipoperoxyl radicals [27], which has been shown [28].…”

Cactus Pear Fruit Extract Exerts Anti-Inflammatory Effects in Carrageenin-Induced Rat Pleurisy

“…A number of recent in vitro studies showed that indicaxanthin is a reducing and amphipathic molecule, able to penetrate cells and membranes and counteract oxidative damage (Butera et al, 2002;Tesoriere et al, 2003Tesoriere et al, , 2005Tesoriere et al, , 2006Tesoriere et al, , 2007Allegra et al, 2005;Liveri et al, 2007;Turco Liveri et al, 2009). In addition, it has been shown to act as a signalling molecule, being able to modulate specific redox-dependent pathways in cultured endothelial cells thus protecting them from dysfunction (Gentile et al, 2004).…”