Kinetics of the release of a drug from a soluble or hydrolyzable polymer matrix

Shurshina, A. S.; Galina, A. R.; Kulish, E. I.

doi:10.1134/s1990793116060129

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…The Hopfenberg release kinetics usually applies to surface-eroding dosage forms and in its expression (Equation (2)), K HF is the Hopfenberg rate constant, which includes the expression K 0 /M 0 a 0 , in which K 0 is the erosion rate constant, M 0 is the initial drug concentration in the dosage form and a 0 is the radius of the sphere or cylinder or the average thickness of the slab (depending on formulation). The variable n H is the Hopfenberg exponent, which is related to the geometry (having a value of 1 for slabs and films, 2 for cylinders and 3 for spheres) [ 42 ].

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Section: Resultsmentioning

confidence: 99%

Amino Functionalized Micro-Mesoporous Hybrid Particles for the Sustained Release of the Antiretroviral Drug Tenofovir

et al. 2020

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The sustained release of an antiretroviral agent to women mucosa has been proved as an excellent strategy to reduce the sexual transmission of HIV. Hybrid micro-mesoporous particles have been synthesized and functionalized with a silane coupling agent followed by loading the antiretroviral tenofovir. It has been observed that the disposition of the silane molecule on the surface of the particles determines the interaction mechanism with the antiretroviral molecule loaded independently on the surface area of the particles. In this sense, available and free amino groups are required to achieve a smart pH-responsive material, a condition that is only achieved in those materials containing a silane chemisorbed monolayer. Moreover, the modulation of the release kinetics attributed to the presence of the silane monolayer covering the mesopores has been confirmed by fitting the releasing curves to the first order and Weibull models. The developed micro-mesoporous particles have been demonstrated to be excellent smart-release vehicles for antiviral agents and can be safely used in polymer mucoadhesive vaginal gels.

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Section: Resultsmentioning

confidence: 99%